Efficient Flow Synthesis of Aspirin within 2D Sub-Nanoconfined Laminar Annealed Graphene Oxide Membranes

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 11 vom: 01. März, Seite e2310954
1. Verfasser:	Li, Xiang (VerfasserIn)
Weitere Verfasser:	Pang, Shuai, Zhang, Yuhui, Fu, Jiangwei, He, Guandi, Song, Bo, Peng, Daoling, Zhang, Xiqi, Jiang, Lei
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article aspirin synthesis directional flow graphene oxide membrane interlayer sub-nanoconfinement mild annealing

Beschreibung
Zusammenfassung:	© 2023 Wiley-VCH GmbH. The aim of this work is to develop an environmentally friendly, safe, and simple route for realizing efficient preparation of aspirin. Here, inspired by enzyme synthesis in vivo, the aspirin synthesis has been realized by sub-nanoconfined esterification with directional flow and ≈100% conversion in an unprecedented reaction time of <6.36 s at 23 °C. Such flow esterification reaction is catalyzed by thermally transformed graphene oxide (GO) membranes with tailored physicochemical properties, which can be obtained simply through a mild annealing method. A possible mechanism is revealed by density functional theory calculation, indicating that the synergistic effect of spatial confinement and surface electronic structure can significantly improve the catalytic performance. By restricting reactants within 2D sub-nano space created by GO-based laminar flow-reactors, the present strategy provides a new route to achieve rapid flow synthesis of aspirin with nearly complete conversion
Beschreibung:	Date Revised 14.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202310954