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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1111/nph.19448
|2 doi
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|a pubmed24n1271.xml
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|a (NLM)38037456
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Huang, Luyao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The fungal pathogen Ustilago maydis targets the maize corepressor RELK2 to modulate host transcription for tumorigenesis
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 26.01.2024
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|a Date Revised 26.01.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors New Phytologist © 2023 New Phytologist Foundation.
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|a Ustilago maydis is a biotrophic fungus that causes tumor formation on all aerial parts of maize. U. maydis secretes effector proteins during penetration and colonization to successfully overcome the plant immune response and reprogram host physiology to promote infection. In this study, we functionally characterized the U. maydis effector protein Topless (TPL) interacting protein 6 (Tip6). We found that Tip6 interacts with the N-terminus of RELK2 through its two Ethylene-responsive element binding factor-associated amphiphilic repression (EAR) motifs. We show that the EAR motifs are essential for the virulence function of Tip6 and critical for altering the nuclear distribution pattern of RELK2. We propose that Tip6 mimics the recruitment of RELK2 by plant repressor proteins, thus disrupting host transcriptional regulation. We show that a large group of AP2/ERF B1 subfamily transcription factors are misregulated in the presence of Tip6. Our study suggests a regulatory mechanism where the U. maydis effector Tip6 utilizes repressive domains to recruit the corepressor RELK2 to disrupt the transcriptional networks of the host plant
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|a Journal Article
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| 650 |
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|a APETALA2/ethylene-responsive factor transcription factors
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| 650 |
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|a EAR motifs
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| 650 |
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4 |
|a TOPLESS
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| 650 |
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4 |
|a Ustilago maydis
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| 650 |
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4 |
|a effector protein
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| 650 |
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|a Co-Repressor Proteins
|2 NLM
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| 650 |
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|a Fungal Proteins
|2 NLM
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| 700 |
1 |
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|a Ökmen, Bilal
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stolze, Sara Christina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kastl, Melanie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khan, Mamoona
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hilbig, Daniel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nakagami, Hirofumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Djamei, Armin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Doehlemann, Gunther
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 241(2024), 4 vom: 14. Jan., Seite 1747-1762
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:241
|g year:2024
|g number:4
|g day:14
|g month:01
|g pages:1747-1762
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| 856 |
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|u http://dx.doi.org/10.1111/nph.19448
|3 Volltext
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|d 241
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|e 4
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|h 1747-1762
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