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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202309261
|2 doi
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|a pubmed25n1216.xml
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|a (DE-627)NLM365075132
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|a (NLM)38016341
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|a DE-627
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|a eng
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|a Jia, Xiuna
|e verfasserin
|4 aut
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|a Rapid Synthesis of Trimetallic Nanozyme for Sustainable Cascaded Catalytic Therapy via Tumor Microenvironment Remodulation
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 16.02.2024
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|a Date Revised 16.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Tumor microenvironment (TME)-responsive nanozyme-catalyzed cancer therapy shows great potential due to its specificity and efficiency. However, breaking the self-adaption of tumors and improving the sustainable remodeling TME ability remains a major challenge for developing novel nanozymes. Here, a rapid method is developed first to synthesize unprecedented trimetalic nanozyme (AuMnCu, AMC) with a targeting peptide (AMCc), which exhibits excellent peroxidase-like, catalase-like, and glucose oxidase-like activities. The released Cu and Mn ions in TME consume endogenous H2 O2 and produce O2 , while the AMCccatalyzes glucose oxidation reaction to generate H2 O2 and gluconic acid, which achieves the starvation therapy by depleting the energy and enhances the chemodynamic therapy effect by lowering the pH of the TME and producing extra H2 O2 . Meanwhile, the reactive oxygen species damage is amplified, as AMCc can constantly oxidize intracellular reductive glutathione through the cyclic valence alternation of Cu and Mn ions, and the generated Cu+ elevate the production of ·OH from H2 O2 . Further studies depict that the well-designed AMCc exhibits the excellent photothermal performance and achieves TME-responsive sustainable starvation/photothermal-enhanced chemodynamic synergistic effects in vitro and in vivo. Overall, a promising approach is demonstrated here to design "all-in-one" nanozyme for theranostics by remodeling the TME
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|a Journal Article
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|a TME remodulation
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|a TME-responsive
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|a antitumor nanozyme
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|a self-replenishing cascaded reactions
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|a synergistic therapy
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|a Coloring Agents
|2 NLM
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|a Glucose
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|a IY9XDZ35W2
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|a Ions
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|a Hydrogen Peroxide
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|a BBX060AN9V
|2 NLM
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| 700 |
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|a Wang, Jin
|e verfasserin
|4 aut
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|a Wang, Erkang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 7 vom: 01. Feb., Seite e2309261
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:36
|g year:2024
|g number:7
|g day:01
|g month:02
|g pages:e2309261
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|u http://dx.doi.org/10.1002/adma.202309261
|3 Volltext
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