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|a 10.1111/jfd.13898
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|a eng
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|a Li, Yuerui
|e verfasserin
|4 aut
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|a Phenotypic and genomic insights into the pathogenicity and antimicrobial resistance of an Enterobacter roggenkampii strain isolated from diseased silver arowana (Osteoglossum bicirrhosum)
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|c 2024
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|a Text
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|a Date Completed 09.02.2024
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|a Date Revised 09.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 John Wiley & Sons Ltd.
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|a Enterobacter roggenkampii is an opportunistic pathogen that causes infections in a wide range of hosts. A bacterial strain named EOBSR_19 was isolated from diseased silver arowana, Osteoglossum bicirrhosum. This bacterium was identified as E. roggenkampii based on the phenotypic characteristics and sequence analysis of the16S rDNA and gyrB genes. Average nucleotide identity and phylogenetic analysis based on the whole genome sequence further confirmed the bacterial taxonomy of EOBSR_19. Artificial experimental infection indicated that EOBSR_19 was pathogenic to fish. Antimicrobial susceptibility test showed it was multi-drug resistant. The EOBSR_19 was found to be resistant to 18 antibiotics belonging to quinolones, macrolides, sulfonamides, aminoglycosides, and β-lactams classes. The whole genome sequencing analysis showed that EOBSR_19 carried 730 virulence genes that were annotated for different functional modules, such as adhesion and invasion, secretion system, siderophore transport system and bacterial toxin. Among them, the virulence genes related to adhesion and invasion were the most abundant. In addition, drug resistance genes involved in multiple mechanisms of antimicrobial resistance were identified in its genomics, including multidrug resistance efflux pumps, antibiotic inactivating enzymes, and antibiotic binding site mutations. Its genomic analysis via whole-genome sequencing provided insights into the pathogenicity and antimicrobial resistance
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|a Journal Article
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|a Enterobacter roggenkampii
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| 650 |
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|a drug resistance genes
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| 650 |
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|a silver arowana
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| 650 |
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4 |
|a virulence genes
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| 650 |
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|a whole genome sequencing
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| 650 |
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|a Anti-Bacterial Agents
|2 NLM
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| 700 |
1 |
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|a Sun, Zhongshi
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 47(2024), 3 vom: 12. März, Seite e13898
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnas
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| 773 |
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|g volume:47
|g year:2024
|g number:3
|g day:12
|g month:03
|g pages:e13898
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|u http://dx.doi.org/10.1111/jfd.13898
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