Injectable Self-Expanding/Self-Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management

Injectable Self-Expanding/Self-Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 15 vom: 04. Apr., Seite e2308701
1. Verfasser: Zhao, Xin (VerfasserIn)
Weitere Verfasser: Huang, Ying, Li, Zhenlong, Chen, Jueying, Luo, Jinlong, Bai, Lang, Huang, Heyuan, Cao, Ertai, Yin, Zhanhai, Han, Yong, Guo, Baolin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article antibacterial hemostats injectable bioadhesives noncompressible hemorrhages procoagulant activity self‐expanding and self‐propelling hydrogels Hydrogels Adhesives Gelatin 9000-70-8 Anti-Bacterial Agents
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520 |a Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and expand to stop lethal and/or noncompressible bleeding in civil and battlefield environments remains a challenge. Herein, an injectable, antibacterial, self-expanding, and self-propelling hydrogel bioadhesive with procoagulant activity and rapid gelation is reported. This hydrogel combines spontaneous gas foaming and rapid Schiff base crosslinking for lethal massive hemorrhage. Hydrogels have rapid gelation and expansion rate, high self-expanding ratio, excellent antibacterial activity, antioxidant efficiency, and tissue adhesion capacity. In addition, hydrogels have good cytocompatibility, procoagulant ability, and higher blood cell/platelet adhesion activity than commercial combat gauze and gelatin sponge. The optimized hydrogel (OD-C/QGQL-A30) exhibits better hemostatic ability than combat gauze and gelatin sponge in rat liver and femoral artery bleeding models, rabbit volumetric liver loss massive bleeding models with/without anticoagulant, and rabbit liver and kidney incision bleeding models with bleeding site not visible. Especially, OD-C/QGQL-A30 rapidly stops the bleedings from pelvic area of rabbit, and swine subclavian artery vein transection. Furthermore, OD-C/QGQL-A30 has biodegradability and biocompatibility, and accelerates Methicillin-resistant S. aureus (MRSA)-infected skin wound healing. This injectable, antibacterial, self-expanding, and self-propelling hydrogel opens up a new avenue to develop hemostats for lethal massive bleeding, abdominal organ bleeding, and bleeding from coagulation lesions 
650 4 |a Journal Article 
650 4 |a antibacterial hemostats 
650 4 |a injectable bioadhesives 
650 4 |a noncompressible hemorrhages 
650 4 |a procoagulant activity 
650 4 |a self‐expanding and self‐propelling hydrogels 
650 7 |a Hydrogels  |2 NLM 
650 7 |a Adhesives  |2 NLM 
650 7 |a Gelatin  |2 NLM 
650 7 |a 9000-70-8  |2 NLM 
650 7 |a Anti-Bacterial Agents  |2 NLM 
700 1 |a Huang, Ying  |e verfasserin  |4 aut 
700 1 |a Li, Zhenlong  |e verfasserin  |4 aut 
700 1 |a Chen, Jueying  |e verfasserin  |4 aut 
700 1 |a Luo, Jinlong  |e verfasserin  |4 aut 
700 1 |a Bai, Lang  |e verfasserin  |4 aut 
700 1 |a Huang, Heyuan  |e verfasserin  |4 aut 
700 1 |a Cao, Ertai  |e verfasserin  |4 aut 
700 1 |a Yin, Zhanhai  |e verfasserin  |4 aut 
700 1 |a Han, Yong  |e verfasserin  |4 aut 
700 1 |a Guo, Baolin  |e verfasserin  |4 aut 
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773 1 8 |g volume:36  |g year:2024  |g number:15  |g day:04  |g month:04  |g pages:e2308701 
856 4 0 |u http://dx.doi.org/10.1002/adma.202308701  |3 Volltext 
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