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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c01906
|2 doi
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|a pubmed25n1214.xml
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|a (DE-627)NLM364549238
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|a (NLM)37963300
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Xiong, Yingshuo
|e verfasserin
|4 aut
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| 245 |
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|a Mechanical Properties of Low-Molecular-Weight Peptide Hydrogels Improved by Thiol-Ene Click Chemistry
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.11.2023
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|a Date Revised 12.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Low-molecular-weight peptide hydrogels can be formed by self-assembly through weak interactions, but the application of the hydrogel is influenced by its weak mechanical properties. Therefore, it is important to construct low-molecular-weight peptide hydrogels with excellent mechanical properties. In this work, we designed the pentapeptide molecule Fmoc-FFCKK-OH (abbreviated as FFCKK) with a sulfhydryl group, and another low-molecular-weight cross-linker N,N'-methylenebis(acrylamide) (MBA) was introduced to construct a hydrogel with excellent mechanical properties. The secondary structure change process of FFCKK and the assembly mechanism of hydrogel were analyzed using theoretical calculations and experimental characterizations. The occurrence of thiol-ene click chemistry provides covalent interaction in the hydrogel, and the synergistic effect ofcovalent interaction and hydrogen bonding improves the mechanical properties of the hydrogel by nearly 10-fold. The hydrogel was observed to be able to withstand a stress of 368 Pa and to break in a layer-by-layer manner by compression testing. The micromechanics of the hydrogels were characterized, and the excellent mechanical properties of the hydrogels were confirmed. The synergistic approach provides a new idea for the preparation of low-molecular-weight peptide hydrogels and facilitates the expansion of their potential applications in biomedical fields
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Hydrogels
|2 NLM
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|a Sulfhydryl Compounds
|2 NLM
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|a Peptides
|2 NLM
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|a Hu, Xiaohan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Junjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Xinze
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xue, Zhongxin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Niu, Yuzhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shaohua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Changmei
|e verfasserin
|4 aut
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| 700 |
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|a Xu, Wenlong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 39(2023), 47 vom: 28. Nov., Seite 16750-16759
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:39
|g year:2023
|g number:47
|g day:28
|g month:11
|g pages:16750-16759
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|u http://dx.doi.org/10.1021/acs.langmuir.3c01906
|3 Volltext
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