Impact of Dyslipidemia Medications on the Prevalence of Diabetic Retinopathy Among a Large US Cohort

BACKGROUND AND OBJECTIVE: Dyslipidemia medications such as statins and fibrates may be associated with a reduction in diabetic retinopathy (DR) progression, but real-world data is lacking. This study evaluates cholesterol-lowering medications and their association with the prevalence of DR and advan...

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Publié dans:Ophthalmic surgery, lasers & imaging retina. - 2013. - 54(2023), 11 vom: 22. Nov., Seite 626-633
Auteur principal: Chadalavada, Srila H (Auteur)
Autres auteurs: Shaia, Jacqueline K, Russell, Matthew W, Talcott, Katherine E, Singh, Rishi P
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Ophthalmic surgery, lasers & imaging retina
Sujets:Journal Article Cholesterol 97C5T2UQ7J Fibric Acids
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245 1 0 |a Impact of Dyslipidemia Medications on the Prevalence of Diabetic Retinopathy Among a Large US Cohort 
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520 |a BACKGROUND AND OBJECTIVE: Dyslipidemia medications such as statins and fibrates may be associated with a reduction in diabetic retinopathy (DR) progression, but real-world data is lacking. This study evaluates cholesterol-lowering medications and their association with the prevalence of DR and advanced DR complications 
520 |a PATIENTS AND METHODS: Data was collected using codes from the International Classification of Diseases on TriNetX, a cross-sectional database of over 79 million Americans, between June and August 2022. Prevalence and prevalence odds ratios (POR) were calculated 
520 |a RESULTS: Patients taking pitavastatin (OR 0.64, 95% CI 0.49, 0.84), fenofibrate (OR 0.83, CI 0.79, 0.87), or evolocumab (OR 0.80, CI 0.68, 0.95) had lower POR of proliferative DR compared to nonproliferative DR. Patients taking any cholesterol medication had a lower POR of vitreous hemorrhage. Patients taking fibrates also had lower POR of neovascular glaucoma 
520 |a CONCLUSION: This exploratory study highlights positive associations between DR and dyslipidemia and medications that may have fewer worsening events in DR patients. [Ophthalmic Surg Lasers Imaging Retina 2023;54:626-633.] 
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700 1 |a Shaia, Jacqueline K  |e verfasserin  |4 aut 
700 1 |a Russell, Matthew W  |e verfasserin  |4 aut 
700 1 |a Talcott, Katherine E  |e verfasserin  |4 aut 
700 1 |a Singh, Rishi P  |e verfasserin  |4 aut 
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