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20231226095101.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.plaphy.2023.108123
|2 doi
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|a pubmed24n1214.xml
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|a (DE-627)NLM364268336
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|a (NLM)37935068
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|a (PII)S0981-9428(23)00634-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Christudoss, Abisha Christy
|e verfasserin
|4 aut
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1 |
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|a Eco-corona formation diminishes the cytogenotoxicity of graphene oxide on Allium cepa
|b Role of soil extracted-extracellular polymeric substances in combating oxidative stress
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.11.2023
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|a Date Revised 29.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Masson SAS. All rights reserved.
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|a Graphene oxide (GO) is widely acknowledged for its exceptional biological and industrial applications. However, its discharge into the environment negatively impacts the ecosystem. This study aimed to investigate the toxicity of GO in Allium cepa root tip cells and the role of extracellular polymeric substances (EPS) in modulating its toxic effects. To evaluate toxicity, various endpoints like cell viability using Evans blue dye, cytotoxicity (mitotic index), genotoxicity (chromosomal aberrations), and oxidative stress assessments (total ROS, superoxide, hydroxyl radical production, and lipid peroxidation) were considered. The results suggest that pristine GO caused a dose-dependent increase in various toxicity parameters, especially the genotoxic effects. Oxidative stress generation by GO is proposed to be the principal mode of action. The EPS-corona formed on GO could potentially counteract the toxic effects, substantially reducing the oxidative stress within the cells
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|a Journal Article
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|a Allium cepa
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|a Chromosomal aberrations
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|a EPS-Coating
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|a Free radical generation
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|a Graphene oxide
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|a Membrane integrity
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|a Mitotic index
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|a graphene oxide
|2 NLM
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|a Soil
|2 NLM
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1 |
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|a Dimkpa, Christian O
|e verfasserin
|4 aut
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1 |
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|a Mukherjee, Amitava
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Plant physiology and biochemistry : PPB
|d 1991
|g 204(2023) vom: 05. Nov., Seite 108123
|w (DE-627)NLM098178261
|x 1873-2690
|7 nnns
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| 773 |
1 |
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|g volume:204
|g year:2023
|g day:05
|g month:11
|g pages:108123
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|u http://dx.doi.org/10.1016/j.plaphy.2023.108123
|3 Volltext
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|d 204
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