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|a 10.1111/jfd.13880
|2 doi
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|a eng
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|a Olsvik, Pål A
|e verfasserin
|4 aut
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|a Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 11.01.2024
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|a Date Revised 16.01.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd.
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|a Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron in liver tissue of Atlantic salmon. Juvenile salmon weighing 40 g were given a standard 7-day oral dose, and bioaccumulation and transcriptional responses in the liver were examined 1 day after the end-of-treatment (day 8) and after 1 week of elimination (day 14). Bioaccumulation levels of lufenuron were 29 ± 3 mg/kg at day 8 and 14 ± 1 mg/kg at day 14, indicating relatively rapid clearance. However, residues of lufenuron were still present in the liver after 513 days of depuration. The exposure gave a transient inhibition of transcription in the liver at day 8 (2437 significant DEGs, p-adj < .05), followed by a weaker compensatory response at day 14 (169 significant DEGs). Pathways associated with RNA metabolism such as the sumoylation pathway were most strongly affected at day 8, while the apelin pathway was most profoundly affected at day 14. In conclusion, this study shows that lufenuron easily bioaccumulates and that a standard 7-day oral dose induces a transient inhibition of transcription in liver of salmon
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|a Journal Article
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|a Atlantic salmon liver tissue
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|a RNA-seq
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|a bioaccumulation
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|a lufenuron
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|a pathway analysis
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|a salmon lice drugs
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| 650 |
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|a fluphenacur
|2 NLM
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|a 1R754M4918
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|a Brokke, Kristine E
|e verfasserin
|4 aut
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|a Samuelsen, Ole B
|e verfasserin
|4 aut
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| 700 |
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|a Hannisdal, Rita
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 47(2024), 2 vom: 02. Feb., Seite e13880
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnas
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|g volume:47
|g year:2024
|g number:2
|g day:02
|g month:02
|g pages:e13880
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|u http://dx.doi.org/10.1111/jfd.13880
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