Aggregation-Induced Emission-Based Macrophage-Like Nanoparticles for Targeted Photothermal Therapy and Virus Transmission Blockage in Monkeypox

Aggregation-Induced Emission-Based Macrophage-Like Nanoparticles for Targeted Photothermal Therapy and Virus Transmission Blockage in Monkeypox

© 2023 Wiley-VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 9 vom: 21. März, Seite e2305378
Auteur principal: Li, Bin (Auteur)
Autres auteurs: Wang, Wei, Zhao, Lu, Li, Mengjun, Yan, Dingyuan, Li, Xiaoxue, Zhang, Jie, Gao, Qiuxia, Feng, Yi, Zheng, Judun, Shu, Bowen, Yan, Yan, Wang, Jiamei, Wang, Huanhuan, He, Lingjie, Wu, Yunxia, Zhou, Sitong, Qin, Xinchi, Chen, Wentao, Qiu, Kaizhen, Shen, Chenguang, Wang, Dong, Tang, Ben Zhong, Liao, Yuhui
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article aggregation-induced emission biomimetic nanoparticles monkeypox targeted photothermal therapy virus transmission blockage
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520 |a The recent prevalence of monkeypox has led to the declaration of a Public Health Emergency of International Concern. Monkeypox lesions are typically ulcers or pustules (containing high titers of replication-competent virus) in the skin and mucous membranes, which allow monkeypox virus to transmit predominantly through intimate contact. Currently, effective clinical treatments for monkeypox are lacking, and strategies for blocking virus transmission are fraught with drawbacks. Herein, this work constructs a biomimetic nanotemplate (termed TBDM NPs) with macrophage membranes as the coat and polymeric nanoparticles loading a versatile aggregation-induced emission featured photothermal molecule TPE-BT-DPTQ as the core. In a surrogate mouse model of monkeypox (vaccinia-virus-infected tail scarification model), intravenously injected TBD@M NPs show precise tracking and near-infrared region II fluorescence imaging of the lesions. Upon 808 nm laser irradiation, the virus is eliminated by the photothermal effect and the infected wound heals rapidly. More importantly, the inoculation of treated lesion tissue suspensions does not trigger tail infection or inflammatory activation in healthy mice, indicating successful blockage of virus transmission. This study demonstrates for the first time monkeypox theranostics using nanomedicine, and may bring a new insight into the development of a viable strategy for monkeypox management in clinical trials 
650 4 |a Journal Article 
650 4 |a aggregation-induced emission 
650 4 |a biomimetic nanoparticles 
650 4 |a monkeypox 
650 4 |a targeted photothermal therapy 
650 4 |a virus transmission blockage 
700 1 |a Wang, Wei  |e verfasserin  |4 aut 
700 1 |a Zhao, Lu  |e verfasserin  |4 aut 
700 1 |a Li, Mengjun  |e verfasserin  |4 aut 
700 1 |a Yan, Dingyuan  |e verfasserin  |4 aut 
700 1 |a Li, Xiaoxue  |e verfasserin  |4 aut 
700 1 |a Zhang, Jie  |e verfasserin  |4 aut 
700 1 |a Gao, Qiuxia  |e verfasserin  |4 aut 
700 1 |a Feng, Yi  |e verfasserin  |4 aut 
700 1 |a Zheng, Judun  |e verfasserin  |4 aut 
700 1 |a Shu, Bowen  |e verfasserin  |4 aut 
700 1 |a Yan, Yan  |e verfasserin  |4 aut 
700 1 |a Wang, Jiamei  |e verfasserin  |4 aut 
700 1 |a Wang, Huanhuan  |e verfasserin  |4 aut 
700 1 |a He, Lingjie  |e verfasserin  |4 aut 
700 1 |a Wu, Yunxia  |e verfasserin  |4 aut 
700 1 |a Zhou, Sitong  |e verfasserin  |4 aut 
700 1 |a Qin, Xinchi  |e verfasserin  |4 aut 
700 1 |a Chen, Wentao  |e verfasserin  |4 aut 
700 1 |a Qiu, Kaizhen  |e verfasserin  |4 aut 
700 1 |a Shen, Chenguang  |e verfasserin  |4 aut 
700 1 |a Wang, Dong  |e verfasserin  |4 aut 
700 1 |a Tang, Ben Zhong  |e verfasserin  |4 aut 
700 1 |a Liao, Yuhui  |e verfasserin  |4 aut 
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