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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c01726
|2 doi
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|a pubmed24n1213.xml
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|a (DE-627)NLM364142979
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|a (NLM)37922445
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Yi, Shui Ling
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 01.12.2023
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|a Date Revised 01.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Transferrin-conjugated polymersomes, transferrin-biotin/avidin/biotin-Pluronic F127-poly(lactic acid) (Tf-F127-PLA), were successfully prepared through a biotin-avidin bridging technique to study their ability to inhibit multidrug resistance of cancer cells. Hydrophilic doxorubicin (DOX) was selected as the model drug to be loaded into Tf-F127-PLA polymersomes. DOX loaded in Tf-F127-PLA polymersomes was released fast initially, followed by a slow release. The effect of the transferrin ligand density of Tf-F127-PLA/DOX polymersomes on their targeting properties was studied by both cytotoxicity and cellular uptake assays against A549 lung cancer cells. It was shown that Tf-F127-PLA/DOX polymersomes had better targeting ability than nontargeted drug-loaded polymersomes. Furthermore, Tf-F127-PLA/DOX polymersomes with 2% Tf molar content have more effective antitumor activity and a higher cellular uptake than those with 4 and 5% Tf molar content. 2% Tf-F127-PLA/DOX polymersomes also exhibited better anticancer ability in multidrug resistant cancer cells A549/ADR than nontargeted PLA-F127-PLA/DOX polymersomes. It was further proved that the endocytosis of polymersomes by A549/ADR cells was an energy-dependent endocytosis process, which was related to clathrin, macrocytosis, and caveolin. Also, the endocytosis of Tf-F127-PLA/DOX polymersomes was proven to be mediated by the transferrin receptor
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Avidin
|2 NLM
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|a 1405-69-2
|2 NLM
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|a Biotin
|2 NLM
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|a 6SO6U10H04
|2 NLM
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|a Doxorubicin
|2 NLM
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|a 80168379AG
|2 NLM
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|a Ligands
|2 NLM
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|a Polyesters
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|a Transferrin
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|a UCON 50-HB-5100
|2 NLM
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|a 9038-95-3
|2 NLM
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| 700 |
1 |
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|a Li, Zi Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gong, Yan Chun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiong, Xiang Yuan
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 39(2023), 45 vom: 14. Nov., Seite 15920-15931
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:39
|g year:2023
|g number:45
|g day:14
|g month:11
|g pages:15920-15931
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|u http://dx.doi.org/10.1021/acs.langmuir.3c01726
|3 Volltext
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