|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM364131411 |
| 003 |
DE-627 |
| 005 |
20240209231945.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231226s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202307627
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1285.xml
|
| 035 |
|
|
|a (DE-627)NLM364131411
|
| 035 |
|
|
|a (NLM)37921269
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liu, Bin
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Protein Nanotubes as Advanced Material Platforms and Delivery Systems
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 09.02.2024
|
| 500 |
|
|
|a Date Revised 09.02.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
|
| 520 |
|
|
|a Protein nanotubes (PNTs) as state-of-the-art nanocarriers are promising for various potential applications both in the food and pharmaceutical industries. Derived from edible starting sources like α-lactalbumin, lysozyme, and ovalbumin, PNTs bear properties of biocompatibility and biodegradability. Their large specific surface area and hydrophobic core facilitate chemical modification and loading of bioactive substances, respectively. Moreover, their enhanced permeability and penetration ability across biological barriers such as intestinal mucus, extracellular matrix, and thrombus clot, make it promising platforms for health-related applications. Most importantly, their simple preparation processes enable large-scale production, supporting applications in the biomedical and nanotechnological fields. Understanding the self-assembly principles is crucial for controlling their morphology, size, and shape, and thus provides the ground to a multitude of applications. Here, the current state-of-the-art of PNTs including their building materials, physicochemical properties, and self-assembly mechanisms are comprehensively reviewed. The advantages and limitations, as well as challenges and prospects for their successful applications in biomaterial and pharmaceutical sectors are then discussed and highlighted. Potential cytotoxicity of PNTs and the need of regulations as critical factors for enabling in vivo applications are also highlighted. In the end, a brief summary and future prospects for PNTs as advanced platforms and delivery systems are included
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Review
|
| 650 |
|
4 |
|a amyloids
|
| 650 |
|
4 |
|a bioactive compounds
|
| 650 |
|
4 |
|a delivery systems
|
| 650 |
|
4 |
|a encapsulation
|
| 650 |
|
4 |
|a nanocarriers
|
| 650 |
|
4 |
|a protein nanotubes
|
| 650 |
|
4 |
|a self-assembly
|
| 650 |
|
7 |
|a Proteins
|2 NLM
|
| 650 |
|
7 |
|a Biocompatible Materials
|2 NLM
|
| 700 |
1 |
|
|a Li, Xing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Ji Peng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Xin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yuan, Yu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hou, Guo Hua
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Hui Juan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Hui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Yuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Mezzenga, Raffaele
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 6 vom: 01. Feb., Seite e2307627
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:36
|g year:2024
|g number:6
|g day:01
|g month:02
|g pages:e2307627
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202307627
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 36
|j 2024
|e 6
|b 01
|c 02
|h e2307627
|