DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection

DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection

Copyright © 2023 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 257(2023) vom: 02. Dez., Seite 109819
1. Verfasser: Lee, Unn Hwa (VerfasserIn)
Weitere Verfasser: Park, Sang Jin, Ju, Seong A, Lee, Sang Chul, Kim, Byung Sam, Ahn, Byungyong, Yi, Jawoon, Park, Jihwan, Won, Young-Wook, Han, In Seob, Lee, Byung Ju, Cho, Wha Ja, Park, Jeong Woo
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't DRG2 Inflammatory response L. monocytogenes NF-κB Tissue-resident macrophages developmentally regulated GTP-binding protein 149371-72-2 GTP-Binding Proteins EC 3.6.1.-
Beschreibung
Zusammenfassung:Copyright © 2023 Elsevier Inc. All rights reserved.
Innate immune response is critical for the control of Listeria monocytogenes infection. Here, we identified developmentally regulated GTP-binding protein 2 (DRG2) in macrophages as a major regulator of the innate immune response against L. monocytogenes infection. Both whole-body DRG2 knockout (KO) mice and macrophage-specific DRG2 KO mice had low levels of IL-6 during early infection and increased susceptibility to L. monocytogenes infection. Following an initial impaired inflammatory response of macrophages upon i.p. L. monocytogenes infection, DRG2-/- mice showed delayed recruitment of neutrophils and monocytes into the peritoneal cavity, which led to elevated bacterial burden, inflammatory cytokine production at a late infection time point, and liver micro-abscesses. DRG2 deficiency decreased the transcriptional activity of NF-κB and impaired the inflammatory response of both bone marrow-derived and peritoneal macrophages upon L. monocytogenes stimulation. Our findings reveal that DRG2 in macrophages is critical for the initial inflammatory response and protection against L. monocytogenes infection
Beschreibung:Date Completed 11.01.2024
Date Revised 10.04.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109819