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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202306248
|2 doi
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|a pubmed24n1536.xml
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|a eng
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| 100 |
1 |
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|a Wang, Yi
|e verfasserin
|4 aut
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| 245 |
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|a Engineered CpG-Loaded Nanorobots Drive Autophagy-Mediated Immunity for TLR9-Positive Cancer Therapy
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 29.05.2024
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|a Date Revised 17.09.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley‐VCH GmbH.
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|a Smart nanorobots have emerged as novel drug delivery platforms in nanomedicine, potentially improving anti-cancer efficacy and reducing side effects. In this study, an intelligent tumor microenvironment-responsive nanorobot is developed that effectively delivers CpG payloads to Toll-like receptor 9 (TLR9)-positive tumors to induce autophagy-mediated cell death for immunotherapy. The nanorobots are fabricated by co-self-assembly of two amphiphilic triblock polymer peptides: one containing the matrix metallopeptidase 2 (MMP2)-cleaved GPLGVRGS motif to control the mechanical opening of the nanorobots and provide targeting capability for TLR-9-positive tumors and the other consisting of an arginine-rich GRRRDRGRS sequence that can condense nuclear acid payloads through electrostatic interactions. Using multiple tumor-bearing mouse models, it is investigated whether the intravenous injection of CpG-loaded nanorobots could effectively deliver CpG payloads to TLR-9-positive tumors and elicit anti-tumor immunity through TLR9 signaling and autophagy. Therefore, besides being a commonly used adjuvant for tumor vaccination, CpG-loaded nanorobots can effectively reprogram the tumor immunosuppressive microenvironment and suppress tumor growth and recurrence. This nanorobot-based CpG immunotherapy can be considered a feasible approach to induce anti-tumor immunity, showing great therapeutic potential for the future treatment of TLR9-positive cancers
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|a Journal Article
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|a CpG
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|a TLR9
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|a autophagy
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| 650 |
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|a cancer immunotherapy
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| 650 |
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|a nanorobots
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| 650 |
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|a Oligodeoxyribonucleotides
|2 NLM
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| 650 |
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|a Toll-Like Receptor 9
|2 NLM
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| 700 |
1 |
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|a Qiao, Sheng-Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Meng-Zhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Nan-Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mamuti, Muhetaerjiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a An, Hong-Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Yao-Xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 22 vom: 01. Mai, Seite e2306248
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:22
|g day:01
|g month:05
|g pages:e2306248
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202306248
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