|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM363715916 |
| 003 |
DE-627 |
| 005 |
20241104232104.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231226s2023 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2023.109814
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1590.xml
|
| 035 |
|
|
|a (DE-627)NLM363715916
|
| 035 |
|
|
|a (NLM)37879380
|
| 035 |
|
|
|a (PII)S1521-6616(23)00577-6
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Chakraborty, Sushmita
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis
|
| 264 |
|
1 |
|c 2023
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 02.01.2024
|
| 500 |
|
|
|a Date Revised 04.11.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2023 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a In Rheumatoid Arthritis (RA), regulatory T cells (Tregs) have been found to be enriched in the synovial fluid. Despite their accumulation, they are unable to suppress synovial inflammation. Recently, we showed the synovial enrichment of interleukin-9 (IL-9) producing helper T cells and its positive correlation with disease activity. Therefore, we investigated the impact of IL-9 on synovial Tregs in RA. Here, we confirmed high synovial Tregs in RA patients, however these cells were functionally impaired in terms of suppressive cytokine production (IL-10 and TGF-β). Abrogating IL-9/ IL-9 receptor interaction could restore the suppressive cytokine production of synovial Tregs and reduce the synovial inflammatory T cells producing IFN-γ, TNF-α, IL-17. However, blocking these inflammatory cytokines failed to show any effect on IL-9 producing T cells, highlighting IL-9's hierarchy in the inflammatory network. Thus, we propose that blocking IL-9 might dampen synovial inflammation by restoring Tregs function and inhibiting inflammatory T cells
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Inflammatory cytokines
|
| 650 |
|
4 |
|a Interleukin −9
|
| 650 |
|
4 |
|a Regulatory T cells
|
| 650 |
|
4 |
|a Rheumatoid arthritis
|
| 650 |
|
4 |
|a Synovial fluid
|
| 650 |
|
7 |
|a Cytokines
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-9
|2 NLM
|
| 700 |
1 |
|
|a Gupta, Ranjan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kubatzky, Katharina F
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kar, Santanu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kraus, Franziska V
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Souto-Carneiro, M Margarida
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lorenz, Hanns-Martin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kumar, Pankaj
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kumar, Vijay
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Mitra, Dipendra Kumar
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 257(2023) vom: 31. Dez., Seite 109814
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:257
|g year:2023
|g day:31
|g month:12
|g pages:109814
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2023.109814
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 257
|j 2023
|b 31
|c 12
|h 109814
|