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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.13877
|2 doi
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|a pubmed25n1211.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Shi, Yan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Role of TRAF6 from obscure puffer (Takifugu obscurus) in immune response against Edwardsiella tarda infection
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| 264 |
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 11.01.2024
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|a Date Revised 11.01.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 John Wiley & Sons Ltd.
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|a Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a vital molecule of inflammatory signaling pathways in innate immune response against pathogens. To elucidate its role in defense against Edwardsiella tarda infection in teleost fish, TRAF6 homologue was identified from obscure puffer (Takifugu obscurus) and functionally analyzed in this study. The obscure puffer TRAF6 (ToTRAF6) is a protein of 565 amino acids containing conserved RING domain, zinc finger-TRAF and MATH_TRAF6 domain. ToTRAF6 mRNA distributed in various healthy tissues of obscure puffer and was upregulated in the immune related tissues after E. tarda infection. ToTRAF6 protein was localized in the cytoplasm and aggregate as dots around the nuclei in FHM cells. The overexpression of ToTRAF6 in FHM cells decreased the quantity of E. tarda and induced the significant upregulation of downstream MAPK signaling pathway genes. These data suggest that ToTRAF6 is a key molecule of MAPK signaling pathway in defense against E. tarda infection
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|a Journal Article
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|a Takifugu obscurus
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| 650 |
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4 |
|a antimicrobial function
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| 650 |
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|a expression pattern
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| 650 |
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4 |
|a signaling pathway
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| 650 |
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|a tumor necrosis factor receptor-associated factor 6
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| 650 |
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|a TNF Receptor-Associated Factor 6
|2 NLM
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| 700 |
1 |
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|a Liang, Xiaying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Sufei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, MengMeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yifan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Zhe
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 47(2024), 2 vom: 24. Feb., Seite e13877
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnas
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| 773 |
1 |
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|g volume:47
|g year:2024
|g number:2
|g day:24
|g month:02
|g pages:e13877
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| 856 |
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|u http://dx.doi.org/10.1111/jfd.13877
|3 Volltext
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