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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202307980
|2 doi
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|a pubmed24n1257.xml
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|a (DE-627)NLM363167579
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|a (NLM)37823714
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wu, Jiyue
|e verfasserin
|4 aut
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|a Ultrasound-Driven Non-Metallic Fenton-Active Center Construction for Extensive Chemodynamic Therapy
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.01.2024
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|a Date Revised 12.01.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Chemodynamic therapy (CDT) is an emerging tumor microenvironment-responsive cancer therapeutic strategy based on Fenton/Fenton-like reactions. However, the effectiveness of CDT is subject to the slow kinetic rate and non-homogeneous distribution of H2 O2 . In this study, a conceptual non-metallic "Fenton-active" center construction strategy is proposed to enhance CDT efficiency using Bi0.44 Ba0.06 Na0.5 TiO2.97 (BNBT-6) nanocrystals. The separated charge carriers under a piezoelectric-induced electric field synchronize the oxidation of H2 O and reduction of H2 O2 , which consequently increases hydroxyl radical (·OH) yield even under low H2 O2 levels. Moreover, acceptor doping induces electron-rich oxygen vacancies to facilitate the dissociation of H2 O2 and H2 O and further promote ·OH generation. In vitro and in vivo experiments demonstrate that BNBT-6 induces extensive intracellular oxidative stress and enhances cell-killing efficiency by activating necroptosis in addition to the conventional apoptotic pathway. This study proposes a novel design approach for nanomaterials used in CDT and presents a new treatment strategy for apoptosis-resistant tumors
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|a Journal Article
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|a Fenton chemistry
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|a chemodynamic therapy
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|a oxygen vacancy
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|a piezoelectric
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|a ultrasound
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|a Hydroxyl Radical
|2 NLM
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|a 3352-57-6
|2 NLM
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|a Hydrogen Peroxide
|2 NLM
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|a BBX060AN9V
|2 NLM
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| 700 |
1 |
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|a Meng, Yun
|e verfasserin
|4 aut
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|a Wu, Fan
|e verfasserin
|4 aut
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1 |
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|a Shi, Jieyun
|e verfasserin
|4 aut
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| 700 |
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|a Sun, Qingwen
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Xingwu
|e verfasserin
|4 aut
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|a Liu, Yanyan
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Peiran
|e verfasserin
|4 aut
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|a Wang, Qiao
|e verfasserin
|4 aut
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1 |
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|a Guo, Lehang
|e verfasserin
|4 aut
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|a Wu, Yelin
|e verfasserin
|4 aut
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|a Zheng, Xiangpeng
|e verfasserin
|4 aut
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| 700 |
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|a Bu, Wenbo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 2 vom: 11. Jan., Seite e2307980
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:2
|g day:11
|g month:01
|g pages:e2307980
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|u http://dx.doi.org/10.1002/adma.202307980
|3 Volltext
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