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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.wasman.2023.09.038
|2 doi
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|a pubmed24n1209.xml
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|a (DE-627)NLM362954798
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|a (NLM)37801871
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|a (PII)S0956-053X(23)00602-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Yao, Mengyao
|e verfasserin
|4 aut
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| 245 |
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|a Butyl benzyl phthalate exposure impact on the gut health of Metaphire guillelmi
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 06.10.2023
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a Copyright © 2023 Elsevier Ltd. All rights reserved.
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|a Agricultural films are extensively utilized in high-intensity agriculture, with China's annual usage reaching 1.5 million tons. Unfortunately, the recovery rate is less than 60%, leading to an inevitable accumulation of plastic mulch in agricultural soils. This accumulation primarily introduces butyl benzyl phthalate (BBP) into soil ecosystems, whose specific effects remain largely unclear, thereby posing potential risks. The present study focuses on the exposure impact of BBP on earthworms, Metaphire guillelmi, a commonly found endogenic earthworm within real farmland, as it provides insight into the direct interaction between biota gut health and contaminants. Specifically, we studied the biomarkers related to oxidative stress, the digestive system, and neurotoxicity within the gut of Metaphire guillelmi, and the integrated biological response (IBR) index was utilized to track these markers at different timeframes after BBP exposures. Our findings indicate that BBP exposures lead to oxidative damage, digestive system inhibition, and neurotoxicity, with IBR indexes of 14.6 and 17.3 on the 14th and 28th days, respectively. Further, the underlying mechanisms at a molecular level through molecular docking were investigated. The results showed that the most unstable interaction was with the Na+K+-ATPase (binding energy: -2.25 kcal-1), while BBP displayed stable bonds with superoxide dismutase and 8-hydroxydeoxyguanosine via hydrogen bonds and hydrophobic interaction. These interactions resulted in changes in protein conformation and their normal physiological functions, offering new insights into the molecular mechanism underlying enzymatic activity changes. This study has significant implications for the prediction of toxicity, environmental risk assessment, and the establishment of regulations related to BBP
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|a Journal Article
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|a BBP
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|a Earthworm
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|a IBR
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|a Molecular docking
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|a Phthalic acid esters
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| 700 |
1 |
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|a Qian, Jingran
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Xiaoni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jilong
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Xiaoqing
|e verfasserin
|4 aut
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| 700 |
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|a Gao, Peng
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Cheng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Waste management (New York, N.Y.)
|d 1999
|g 171(2023) vom: 04. Okt., Seite 443-451
|w (DE-627)NLM098197061
|x 1879-2456
|7 nnns
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| 773 |
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|g volume:171
|g year:2023
|g day:04
|g month:10
|g pages:443-451
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|u http://dx.doi.org/10.1016/j.wasman.2023.09.038
|3 Volltext
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