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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1111/nph.19287
|2 doi
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|a pubmed24n1651.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Xie, Bao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.01.2024
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|a Date Revised 04.01.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors New Phytologist © 2023 New Phytologist Foundation.
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|a Nuclear pore complex (NPC) is composed of multiple nucleoporins (Nups). A plethora of studies have highlighted the significance of NPC in plant immunity. However, the specific roles of individual Nups are poorly understood. NUCLEAR PORE ANCHOR (NUA) is a component of NPC. Loss of NUA leads to an increase in SUMO conjugates and pleiotropic developmental defects in Arabidopsis thaliana. Herein, we revealed that NUA is required for plant defense against multiple pathogens. NUCLEAR PORE ANCHOR associates with the transcriptional corepressor TOPLESS-RELATED1 (TPR1) and contributes to TPR1 deSUMOylation. Significantly, NUA-interacting protein EARLY IN SHORT DAYS 4 (ESD4), a SUMO protease, specifically deSUMOylates TPR1. It has been previously established that the SUMO E3 ligase SAP AND MIZ1 DOMAIN-CONTAINING LIGASE 1 (SIZ1)-mediated SUMOylation of TPR1 represses the immune-related function of TPR1. Consistent with this notion, the hyper-SUMOylated TPR1 in nua-3 leads to upregulated expression of TPR1 target genes and compromised TPR1-mediated disease resistance. Taken together, our work uncovers a mechanism by which NUA positively regulates plant defense responses by coordination with ESD4 to deSUMOylate TPR1. Our findings, together with previous studies, reveal a regulatory module in which SIZ1 and NUA/ESD4 control the homeostasis of TPR1 SUMOylation to maintain proper immune output
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|a Journal Article
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|a Arabidopsis
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|a ESD4
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|a NUA
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|a TPR1
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|a deSUMOylation
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|a nuclear pore complex
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|a plant immunity
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|a Arabidopsis Proteins
|2 NLM
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|a Ligases
|2 NLM
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|a EC 6.-
|2 NLM
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|a SIZ1 protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 6.3.2.-
|2 NLM
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| 650 |
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|a Ubiquitin-Protein Ligases
|2 NLM
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| 650 |
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|a EC 2.3.2.27
|2 NLM
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| 650 |
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|a NUA protein, Arabidopsis
|2 NLM
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| 650 |
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|a ESD4 protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 3.4.22.-
|2 NLM
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| 650 |
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|a topless-related 1 protein, Arabidopsis
|2 NLM
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| 700 |
1 |
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|a Luo, Mingyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Qiuyi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shao, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Desheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Somers, David E
|e verfasserin
|4 aut
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| 700 |
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|a Tang, Dingzhong
|e verfasserin
|4 aut
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| 700 |
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|a Shi, Hua
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 241(2024), 1 vom: 01. Jan., Seite 363-377
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:241
|g year:2024
|g number:1
|g day:01
|g month:01
|g pages:363-377
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| 856 |
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|u http://dx.doi.org/10.1111/nph.19287
|3 Volltext
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|d 241
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|h 363-377
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