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20231226091710.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109795
|2 doi
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|a pubmed24n1208.xml
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|a (DE-627)NLM362660212
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|a (NLM)37769786
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|a (PII)S1521-6616(23)00558-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Seitz, V
|e verfasserin
|4 aut
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1 |
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|a Specific T-cell receptor beta-rearrangements of gluten-triggered CD8+ T-cells are enriched in celiac disease patients' duodenal mucosa
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 06.11.2023
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|a Date Revised 06.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023. Published by Elsevier Inc.
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|a Celiac disease (CeD) is an autoimmune disorder affecting the small intestine with gluten as disease trigger. Infections including Influenza A, increase the CeD risk. While gluten-specific CD4+ T-cells, recognizing HLA-DQ2/DQ8 presented gluten-peptides, initiate and sustain the celiac immune response, CD8+ α/β intraepithelial T-cells elicit mucosal damage. Here, we subjected TCRs from a cohort of 56 CeD patients and 22 controls to an analysis employing 749 published CeD-related TCRβ-rearrangements derived from gluten-specific CD4+ T-cells and gluten-triggered peripheral blood CD8+ T-cells. We show, that in addition to TCRs from gluten-specific CD4+ T-cells, TCRs of gluten-triggered CD8+ T-cells are significantly enriched in CeD duodenal tissue samples. TCRβ-rearrangements of gluten-triggered CD8+ T-cells were even more expanded in patients than TCRs from gluten-specific CD4+ T-cells (p < 0.0002) and highest in refractory CeD. Sequence alignments with TCR-antigen databases suggest that a subgroup of these most likely indirectly gluten-triggered TCRs recognize microbial, viral, and autoantigens
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Celiac disease
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| 650 |
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|a Influenza A
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|a Refractory celiac disease
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|a Somatic recombination
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|a T-cell receptor
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| 650 |
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|a Glutens
|2 NLM
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| 650 |
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|a 8002-80-0
|2 NLM
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| 650 |
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|a Receptors, Antigen, T-Cell, alpha-beta
|2 NLM
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| 650 |
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7 |
|a Receptors, Antigen, T-Cell
|2 NLM
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| 700 |
1 |
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|a Gennermann, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elezkurtaj, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Groth, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schaper, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dröge, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lachmann, N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Berg, E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lenze, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kühl, A A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Husemann, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kleo, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Horst, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lennerz, V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hennig, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hummel, M
|e verfasserin
|4 aut
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| 700 |
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|a Schumann, M
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 256(2023) vom: 31. Nov., Seite 109795
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:256
|g year:2023
|g day:31
|g month:11
|g pages:109795
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109795
|3 Volltext
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 256
|j 2023
|b 31
|c 11
|h 109795
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