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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202308640
|2 doi
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|a pubmed24n1264.xml
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|a (DE-627)NLM362438927
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|a (NLM)37747462
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|a DE-627
|b ger
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|e rakwb
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|a eng
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|a Sterin, Ilya
|e verfasserin
|4 aut
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|a Electrochemical and Biocatalytic Signal-Controlled Payload Release from a Metal-Organic Framework
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|c 2024
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|a Text
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 19.01.2024
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|a Date Revised 19.01.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a A metal-organic framework (MOF), ZIF-8, which is stable at neutral and slightly basic pH values in aqueous solutions and destabilized/dissolved under acidic conditions, is loaded with a pH-insensitive fluorescent dye, rhodamine-B isothiocyanate, as a model payload species. Then, the MOF species are immobilized at an electrode surface. The local (interfacial) pH value is rapidly decreased by means of an electrochemically stimulated ascorbate oxidation at +0.4 V (Ag/AgCl/KCl). Oxygen reduction upon switching the applied potential to -0.8 V allows to return the local pH to the neutral/basic pH, then stopping rapidly the release process. The developed method allows electrochemical control over stimulated or inhibited payload release processes from the MOF. The pH variation proceeds in a thin film of the solution near the electrode surface. The switchable release process is realized in a buffer solution and undiluted human serum. As the second option, the pH decrease stimulating the release process is achieved upon an enzymatic reaction using esterase and ester substrate. This approach potentially allows the release activation controlled by numerous enzymes assembled in complex biocatalytic cascades. It is expected that related electrochemical or biocatalytic systems can represent novel signal-responding materials with switchable features for delivering (bio)molecules within biomedical applications
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|a Journal Article
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|a MOFs
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|a electrochemistry
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|a enzymes
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|a local pH changes
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|a metal-organic frameworks
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|a modified electrodes
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|a Metal-Organic Frameworks
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|a Esterases
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|a EC 3.1.-
|2 NLM
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|a Water
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|a 059QF0KO0R
|2 NLM
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|a Fluorescent Dyes
|2 NLM
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|a Hadynski, John
|e verfasserin
|4 aut
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|a Tverdokhlebova, Anna
|e verfasserin
|4 aut
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|a Masi, Madeline
|e verfasserin
|4 aut
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|a Katz, Evgeny
|e verfasserin
|4 aut
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|a Wriedt, Mario
|e verfasserin
|4 aut
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|a Smutok, Oleh
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 3 vom: 01. Jan., Seite e2308640
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:3
|g day:01
|g month:01
|g pages:e2308640
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|u http://dx.doi.org/10.1002/adma.202308640
|3 Volltext
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