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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109780
|2 doi
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|a pubmed24n1207.xml
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|a (DE-627)NLM362380031
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|a (PII)S1521-6616(23)00543-0
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Zhou, Juan
|e verfasserin
|4 aut
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|a NKG2D receptor regulates CD4+T cell differentiation via interaction with dendritic cells in patients with juvenile idiopathic arthritis
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.11.2023
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|a Date Revised 07.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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|a NKG2D provides a costimulatory signal for activation of CD4+ T cells. We explored its role in interactions of CD4+ T cells and dendritic cells (DCs) in juvenile idiopathic arthritis (JIA) patients by using NKG2D genetically modified CD4+ T cells. We found active JIA patients had significantly higher content of CD4 + NKG2D+ T cells than healthy controls. Expression of NKG2D on CD4+ T cells, and MICA and MICB on DCs were significantly greater in articular JIA than systemic JIA. NKG2D induced IL- 12 and suppressed IL-10 and TGF-β from CD4+ T cells, increased IFN-γ + CD4+ T and IL-17+ CD4+ T cells, RORc and T-bet, but reduced CD25+ Foxp3+ CD4+ T cells, IL-4+ CD4+ T cells, Foxp3, and GATA3 in JIA patients. NKG2D decreased IL-10 and increased CD83, MICA, and MICB of DCs in JIA and controls. So NKG2D regulates differentiation of CD4+ T cells directly and the maturation of DCs indirectly
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CD4(+) T cell
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|a Dendritic cell
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|a Differentiation
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|a Juvenile idiopathic arthritis
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|a NKG2D
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|a Forkhead Transcription Factors
|2 NLM
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|a Interleukin-10
|2 NLM
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|a 130068-27-8
|2 NLM
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| 650 |
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|a NK Cell Lectin-Like Receptor Subfamily K
|2 NLM
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| 650 |
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|a KLRK1 protein, human
|2 NLM
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| 700 |
1 |
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|a Wang, Junyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tao, Linlin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Mingyue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Xuemei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Xiaoping
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 256(2023) vom: 21. Nov., Seite 109780
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:256
|g year:2023
|g day:21
|g month:11
|g pages:109780
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|u http://dx.doi.org/10.1016/j.clim.2023.109780
|3 Volltext
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