Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS-Independent Antibacterial Properties Promote Diabetic Wound Healing

Détails bibliographiques
Publié dans:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 8 vom: 06. Feb., Seite e2306292
Auteur principal:	Guo, Yaru (Auteur)
Autres auteurs:	Ding, Shuai, Shang, Changshuai, Zhang, Chenguang, Li, Menggang, Zhang, Qinghua, Gu, Lin, Heng, Boon Chin, Zhang, Shihan, Mei, Feng, Huang, Ying, Zhang, Xuehui, Xu, Mingming, Jiang, Jiuhui, Guo, Shaojun, Deng, Xuliang, Chen, Lili
Format:	Article en ligne
Langue:	English
Publié:	2024
Accès à la collection:	Advanced materials (Deerfield Beach, Fla.)
Sujets:	Journal Article angiogenesis diabetes mellitus nanosheets reactive oxygen species wound healing Reactive Oxygen Species Anti-Bacterial Agents Biocompatible Materials Hydrogels

Description
Résumé:	© 2023 Wiley-VCH GmbH. Nanozymes, as one of the most efficient reactive oxygen species (ROS)-scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving the catalytic efficiency of Pt-based nanozymes (e.g., PtCu, one of the best systems), they still display quite limited ROS scavenging capacity and ROS-dependent antibacterial effects on bacteria or immunocytes, which leads to uncontrolled and poor diabetic wound healing. Hence, a new class of multifunctional PtCuTe nanosheets with excellent catalytic, ROS-independent antibacterial, proangiogenic, anti-inflammatory, and immuno-modulatory properties for boosting the diabetic wound healing, is reported. The PtCuTe nanosheets show stronger ROS scavenging capacity and better antibacterial effects than PtCu. It is also revealed that the PtCuTe can enhance vascular tube formation, stimulate macrophage polarization toward the M2 phenotype and improve fibroblast mobility, outperforming conventional PtCu. Moreover, PtCuTe promotes crosstalk between different cell types to form a positive feedback loop. Consequently, PtCuTe stimulates a proregenerative environment with relevant cell populations to ensure normal tissue repair. Utilizing a diabetic mouse model, it is demonstrated that PtCuTe significantly facilitated the regeneration of highly vascularized skin, with the percentage of wound closure being over 90% on the 8th day, which is the best among the reported comparable multifunctional biomaterials
Description:	Date Completed 23.02.2024 Date Revised 23.02.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202306292