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|a 10.1002/adma.202304845
|2 doi
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|a pubmed24n1285.xml
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|a eng
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| 100 |
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|a Liu, Dan
|e verfasserin
|4 aut
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| 245 |
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|a Tumor Microenvironment-Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 09.02.2024
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|a Date Revised 09.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Insufficient activation of the stimulator of interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits the effect of cancer immunotherapy. Herein, tumor microenvironment (TME)-responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING and Toll-like receptor 4 (TLR4) to augment STING activation via TLR4-mediated nuclear factor-kappa B signaling pathway stimulation, leading to the increased secretion of type I interferons (i.e., 4.0-fold enhancement of IFN-β) and pro-inflammatory cytokines to promote a specific T cell immune response. Moreover, PMM NPs relieve the immunosuppression of the TME by decreasing the percentage of regulatory T cells, and polarizing M2 macrophages to the M1 type, thus creating an immune-supportive TME to unleash a cascade adaptive immune response. Combined with an anti-PD-1 antibody, synergistic efficacy is achieved in both inflamed colorectal cancer and noninflamed metastatic breast tumor models. Moreover, rechallenging tumor-free animals with homotypic cells induced complete tumor rejection, indicating the generation of systemic antitumor memory. These TME-responsive nanoparticles may open a new avenue to achieve the spatiotemporal orchestration of STING activation, providing a promising clinical candidate for next-generation cancer immunotherapy
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|a Journal Article
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|a STING pathway
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|a TLR4 pathway
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| 650 |
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|a cancer immunotherapy
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| 650 |
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|a nanoparticles
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|a tumor microenvironment
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| 650 |
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|a Toll-Like Receptor 4
|2 NLM
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| 700 |
1 |
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|a Liang, Shuang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Kongshuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meng, Qian-Fang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xingang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Jian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Mengli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yun, Kaiqing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Yuanwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rao, Lang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiaoyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zhaohui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 6 vom: 08. Feb., Seite e2304845
|w (DE-627)NLM098206397
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|g volume:36
|g year:2024
|g number:6
|g day:08
|g month:02
|g pages:e2304845
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|u http://dx.doi.org/10.1002/adma.202304845
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