Pure shift FESTA : An ultra-high resolution NMR tool for the analysis of complex fluorine-containing spin systems
© 2023 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.
| Publié dans: | Magnetic resonance in chemistry : MRC. - 1985. - 61(2023), 11 vom: 27. Nov., Seite 606-614 |
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| Auteur principal: | |
| Autres auteurs: | , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2023
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| Accès à la collection: | Magnetic resonance in chemistry : MRC |
| Sujets: | Journal Article 19F 1H FESTA NMR betamethasone decoupling fluoroproline pure shift ultra-high resolution |
| Résumé: | © 2023 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd. NMR measurements of molecules containing sparse fluorine atoms are becoming increasingly common due to their prevalence in medicinal chemistry. However, the presence of both homonuclear and heteronuclear scalar couplings severely complicates their analysis by NMR. In complex systems, FESTA, a heteronuclear spectral editing method, allows simplified 1 H NMR spectra to be obtained containing only 1 H signals from the same spin system as a chosen 19 F. Despite spectral simplification, signal overlap due to the presence of scalar couplings is often a problem in FESTA spectra. Here, we report a new experiment that combines FESTA and pure shift methods to provide fully decoupled ultra-high resolution FESTA spectra showing a single signal for each 1 H chemical environment. The utility of the method is demonstrated for the analysis of two complex fluorine-containing mixtures of pharmaceutical and biochemical interest |
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| Description: | Date Revised 05.10.2023 published: Print-Electronic Citation Status Publisher |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.5393 |