|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM36179178X |
| 003 |
DE-627 |
| 005 |
20240114234224.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231226s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202305468
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1257.xml
|
| 035 |
|
|
|a (DE-627)NLM36179178X
|
| 035 |
|
|
|a (NLM)37681640
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Meng, Qingchen
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a High-Strength Smart Microneedles with "Offensive and Defensive" Effects for Intervertebral Disc Repair
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 12.01.2024
|
| 500 |
|
|
|a Date Revised 12.01.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2023 Wiley-VCH GmbH.
|
| 520 |
|
|
|a Intervertebral disc degeneration (IVDD) is a global public health issue. The injury of annulus fibrosus (AF) caused by acupuncture or discectomy can trigger IVDD again. However, there is currently no suitable method for treating AF injury. In this study, the high-strength smart microneedles (MNs) which can penetrate the AF tissue through a local and minimally invasive method, and achieve remote control of speeded-up release of the drug and hyperthermia by the Near Infrared is developed. The PDA/GelMA composite MNs loaded with diclofenac sodium are designed to extracellularly "offend" the inflammatory microenvironment and mitigate damage to cells, and intracellularly increase the level of cytoprotective heat shock proteins to enhance the defense against the hostile microenvironment, achieving "offensive and defensive" effects. In vitro experiments demonstrate that the synergistic treatment of photothermal therapy and anti-inflammation effectively reduces inflammation, inhibits cell apoptosis, and promotes the synthesis of the extracellular matrix (ECM). In vivo experiments show that the MNs mitigate the inflammatory response, promote ECM deposition, reduce the level of apoptosis, and restore the biomechanical properties of the intervertebral disc (IVD) in rats. Overall, this high-strength smart MNs display promising "offensive and defensive" effects that can provide a new strategy for IVD repair
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a intervertebral disc
|
| 650 |
|
4 |
|a microneedles
|
| 650 |
|
4 |
|a photothermal therapy
|
| 650 |
|
4 |
|a tissue engineering
|
| 650 |
|
7 |
|a Anti-Inflammatory Agents
|2 NLM
|
| 700 |
1 |
|
|a Xie, En
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sun, Heng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Huan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Jiaying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Zhao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Kexin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hu, Jie
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Qianglong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Chaoyong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Bin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Han, Fengxuan
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 2 vom: 08. Jan., Seite e2305468
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:36
|g year:2024
|g number:2
|g day:08
|g month:01
|g pages:e2305468
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202305468
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 36
|j 2024
|e 2
|b 08
|c 01
|h e2305468
|