Mechano-Activated Cell Therapy for Accelerated Diabetic Wound Healing

Mechano-Activated Cell Therapy for Accelerated Diabetic Wound Healing

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 47 vom: 20. Nov., Seite e2304638
1. Verfasser: Shou, Yufeng (VerfasserIn)
Weitere Verfasser: Le, Zhicheng, Cheng, Hong Sheng, Liu, Qimin, Ng, Yi Zhen, Becker, David Laurence, Li, Xianlei, Liu, Ling, Xue, Chencheng, Yeo, Natalie Jia Ying, Tan, Runcheng, Low, Jessalyn, Kumar, Arun R K, Wu, Kenny Zhuoran, Li, Hua, Cheung, Christine, Lim, Chwee Teck, Tan, Nguan Soon, Chen, Yongming, Liu, Zhijia, Tay, Andy
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cell therapy diabetic wounds dynamic mechanical stimulation magnetic hydrogels regenerative medicine Collagen 9007-34-5 Hydrogels
Beschreibung
Zusammenfassung:© 2023 Wiley-VCH GmbH.
Chronic diabetic wounds are a significant global healthcare challenge. Current strategies, such as biomaterials, cell therapies, and medical devices, however, only target a few pathological features and have limited efficacy. A powerful platform technology combining magneto-responsive hydrogel, cells, and wireless magneto-induced dynamic mechanical stimulation (MDMS) is developed to accelerate diabetic wound healing. The hydrogel encapsulates U.S. Food and Drug Administration (FDA)-approved fibroblasts and keratinocytes to achieve ∼3-fold better wound closure in a diabetic mouse model. MDMS acts as a nongenetic mechano-rheostat to activate fibroblasts, resulting in ∼240% better proliferation, ∼220% more collagen deposition, and improved keratinocyte paracrine profiles via the Ras/MEK/ERK pathway to boost angiogenesis. The magneto-responsive property also enables on-demand insulin release for spatiotemporal glucose regulation through increasing network deformation and interstitial flow. By mining scRNAseq data, a mechanosensitive fibroblast subpopulation is identified that can be mechanically tuned for enhanced proliferation and collagen production, maximizing therapeutic impact. The "all-in-one" system addresses major pathological factors associated with diabetic wounds in a single platform, with potential applications for other challenging wound types
Beschreibung:Date Completed 24.11.2023
Date Revised 24.11.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202304638