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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109760
|2 doi
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|a pubmed25n1205.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Lee, Silvia
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Markers of terminally differentiated T-cells as predictors of vascular health in renal transplant recipients and healthy adults
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|c 2023
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|a Text
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|a ƒaComputermedien
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|a Date Completed 23.10.2023
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|a Date Revised 06.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023. Published by Elsevier Inc.
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|a Meta-analyses confirm a link between persistent human cytomegalovirus (HCMV) infections and cardiovascular disease, but the mechanisms are unclear. We assess whether proportions of T-cell populations are reliable predictors of subclinical atherosclerosis and/or reflect the burden of HCMV in healthy adults and renal transplant recipients (RTR). Samples were collected from healthy adults and RTR at baseline (T0) and after 32 (24-40) months (T1). Left carotid intima media thickness (cIMT) and proportions of T-cells expressing CD57, LIR-1 or the TEMRA phenotype increased in healthy adults and RTR. The T-cell populations correlated with levels of HCMV-reactive antibodies. Proportions of CD57+, LIR-1+ and TEMRA CD8+ T-cells correlated with left and right cIMT in healthy adults. Proportions of CD57+ and LIR-1+ CD8+ T-cells at T0 predicted left cIMT at T1 among healthy adults, but these associations disappeared after adjustment for covariates. We link LIR-1+ and CD57+CD8+ T-cells with the progression of cIMT in healthy adults
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Human cytomegalovirus
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| 650 |
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4 |
|a Terminally differentiated T-cells
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| 650 |
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|a Vascular health
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| 700 |
1 |
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|a Chih, HuiJun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Affandi, Jacquita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Waters, Shelley
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Irish, Ashley
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Price, Patricia
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 255(2023) vom: 15. Okt., Seite 109760
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|x 1521-7035
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|g volume:255
|g year:2023
|g day:15
|g month:10
|g pages:109760
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|u http://dx.doi.org/10.1016/j.clim.2023.109760
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