The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 255(2023) vom: 01. Okt., Seite 109762
1. Verfasser: Föhse, Konstantin (VerfasserIn)
Weitere Verfasser: Geckin, Büsra, Zoodsma, Martijn, Kilic, Gizem, Liu, Zhaoli, Röring, Rutger J, Overheul, Gijs J, van de Maat, Josephine, Bulut, Ozlem, Hoogerwerf, Jacobien J, Ten Oever, Jaap, Simonetti, Elles, Schaal, Heiner, Adams, Ortwin, Müller, Lisa, Ostermann, Philipp Niklas, van de Veerdonk, Frank L, Joosten, Leo A B, Haagmans, Bart L, van Crevel, Reinout, van Rij, Ronald P, GeurtsvanKessel, Corine, de Jonge, Marien I, Li, Yang, Domínguez-Andrés, Jorge, Netea, Mihai G
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article BNT162b2 COVID-19 Innate immune response SARS-CoV-2
Beschreibung
Zusammenfassung:Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
The mRNA-based BNT162b2 protects against severe disease and mortality caused by SARS-CoV-2 via induction of specific antibody and T-cell responses. Much less is known about its broad effects on immune responses against other pathogens. Here, we investigated the adaptive immune responses induced by BNT162b2 vaccination against various SARS-CoV-2 variants and its effects on the responsiveness of immune cells upon stimulation with heterologous stimuli. BNT162b2 vaccination induced effective humoral and cellular immunity against SARS-CoV-2 that started to wane after six months. We also observed long-term transcriptional changes in immune cells after vaccination. Additionally, vaccination with BNT162b2 modulated innate immune responses as measured by inflammatory cytokine production after stimulation - higher IL-1/IL-6 release and decreased IFN-α production. Altogether, these data expand our knowledge regarding the overall immunological effects of this new class of vaccines and underline the need for additional studies to elucidate their effects on both innate and adaptive immune responses
Beschreibung:Date Revised 28.09.2023
published: Print-Electronic
Citation Status Publisher
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109762