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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202306469
|2 doi
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|a pubmed24n1205.xml
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|a (DE-627)NLM361674937
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|a (NLM)37669827
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hu, Ruizhi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Liquid Nanoparticles for Nanocatalytic Cancer Therapy
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 29.11.2023
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|a Date Revised 29.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion-involved cancer-therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate from this critical issue, the glutathione (GSH)-responsive organosilica network is employed to lock the liquid drops at the nanoscale via a general bottom-up strategy to achieve the systemic delivery of "ion drugs". In this work, a sulfate radical generation donor (Na2 S2 O8 ), as a paradigm "ion drug", is entrapped into this liquid nanoparticle for efficiently delivering to the tumor region. After further surface engineering with pH-responsive tannic acid-Fe2+ framework, these liquid nanoparticles achieve tumor-microenvironmental pH/GSH-dual responsive ion release (Fe2+ /Na+ /S2 O8 2- ) after reaching the tumor sites, where the Fe2+ further triggers S2 O8 2- to generate toxic •SO4 - and •OH, effectively executing cancer cell ferroptosis (Fe2+ , reactive oxygen species-ROS) and pyroptosis (Na+ , ROS). Such a tumor-responsive/specific liquid nanoplatform is highly instructive for further ion-mediated nanomedicine and disease treatment
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|a Journal Article
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|a liquid nanoparticles
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|a nanocatalytic medicine
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|a sulfate radical
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|a tumor microenvironment
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|a Reactive Oxygen Species
|2 NLM
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| 700 |
1 |
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|a Chen, Xiaoying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Zhifang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Guojun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dai, Chen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Bo
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 48 vom: 05. Nov., Seite e2306469
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g volume:35
|g year:2023
|g number:48
|g day:05
|g month:11
|g pages:e2306469
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| 856 |
4 |
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|u http://dx.doi.org/10.1002/adma.202306469
|3 Volltext
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