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|a 10.1111/vcp.13282
|2 doi
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|a DE-627
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| 041 |
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|a eng
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| 100 |
1 |
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|a Palić, Jelena
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Cytologic, histopathologic, and immunohistochemical features of keloidal fibroma in a dog
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| 264 |
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 29.12.2023
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|a Date Revised 29.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2023 American Society for Veterinary Clinical Pathology.
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|a A five-year-old male English Bulldog was presented with a firm, well-circumscribed, 1 cm in diameter cutaneous mass on the left flank. Fine-needle aspiration (FNA) biopsy samples were collected for cytologic analysis. Cytology revealed a highly cellular sample consisting of spindle cells, numerous bundles of thick, glassy eosinophilic material (hyalinized collagen), and inflammatory cells. Spindle cells showed moderate anisocytosis and anisokaryosis, had oval nuclei with coarsely stippled chromatin, 1-3 prominent round nucleoli, and moderate amounts of wispy cytoplasm. Cells were occasionally associated with an eosinophilic extracellular matrix. Binucleated and trinucleated spindle cells were often noted. Low numbers of macrophages, small lymphocytes, and individual well-granulated mast cells were also present. The lesion was excised and submitted for histopathologic examination, revealing a well-delineated, nonencapsulated mass composed of hyalinized collagen fibers separated by spindle-shaped mesenchymal cells in the deep dermis and subcutis. Mild anisocytosis and anisokaryosis and less than one mitosis per 10 × high power fields were present. Excision of the mass was complete. The findings were consistent with a keloidal fibroma, a rare benign variant of fibroma. Neoplastic cells showed positive immunoreactivity for vimentin, and a small-to-moderate number of tumor cells showed positive immunoreactivity for α-smooth muscle actin. This is the first cytologic description of a keloidal fibroma correlated with histopathologic findings and immunolabeling. In cases where keloidal neoplasia is suspected, and since moderate cellular atypia can be present on cytologic examination even in cases of keloidal fibroma, histopathologic examination is necessary to differentiate between keloidal fibroma and keloidal fibrosarcoma
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| 650 |
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|a Case Reports
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a fibrosarcoma
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| 650 |
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4 |
|a hyalinized collagen
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| 650 |
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4 |
|a keloid
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| 650 |
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4 |
|a skin tumor
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| 650 |
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|a Collagen
|2 NLM
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| 650 |
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|a 9007-34-5
|2 NLM
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| 700 |
1 |
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|a Saey, Veronique
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van der Lugt, Jaco
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Baumgärtner, Wolfgang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hülskötter, Kirsten
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 52(2023), 4 vom: 16. Dez., Seite 676-680
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnas
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|g volume:52
|g year:2023
|g number:4
|g day:16
|g month:12
|g pages:676-680
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|u http://dx.doi.org/10.1111/vcp.13282
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