Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children

Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 255(2023) vom: 03. Okt., Seite 109751
1. Verfasser: Amodio, Donato (VerfasserIn)
Weitere Verfasser: Pascucci, Giuseppe Rubens, Cotugno, Nicola, Rossetti, Chiara, Manno, Emma Concetta, Pighi, Chiara, Morrocchi, Elena, D'Alessandro, Annamaria, Perrone, Marco Alfonso, Valentini, Alessandra, Franceschini, Alessio, Chinali, Marcello, Deodati, Annalisa, Azzari, Chiara, Rossi, Paolo, Cianfarani, Stefano, Andreani, Marco, Porzio, Ottavia, Palma, Paolo
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Androgens COVID-19 Myocarditis Proteomics Vaccine adverse events mRNA COVID-19 vaccination COVID-19 Vaccines
Beschreibung
Zusammenfassung:Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MIS-C compared to c-AEFI, whereas a higher level in proteins related to myocardial injury was found in c-AEFI. In addition, higher levels of DHEAS, DHEA, and cortisone were found in c-AEFI which persisted at follow-up. No anti-heart muscle and anti-endothelial cell antibodies have been detected. Overall current comparative data showed a distinct inflammatory and androgens profile in c-AEFI patients which results to be well restricted on heart and to persist months after the acute event
Beschreibung:Date Completed 02.10.2023
Date Revised 13.12.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109751