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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202303821
|2 doi
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|a pubmed24n1204.xml
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|a (DE-627)NLM36141370X
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|a (NLM)37643459
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhang, Yue
|e verfasserin
|4 aut
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| 245 |
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|a Interfacial Polymerization Produced Magnetic Particles with Nano-Filopodia for Highly Accurate Liquid Biopsy in the PSA Gray Zone
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.11.2023
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|a Date Revised 29.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Magnetic particles are leading separation materials for biological purification and detection. Existing magnetic particles, which almost rely on molecule-level interactions, however, often encounter bottlenecks in highly efficient cell-level separation due to the underestimate of surface structure effects. Here, immune cell-inspired magnetic particles with nano-filopodia (NFMPs) produced by interfacial polymerization for highly efficient capture of circulating tumor cells (CTCs) and further accurate clinical diagnosis of prostate cancer are reported . The unprecedented construction of nano-filopodia on polymer-based magnetic particles is achieved by introducing electrostatic interactions in emulsion interfacial polymerization. Due to the unique nano-filopodia, the NFMPs allow remarkably enhanced CTCs capture efficiency (86.5% ± 2.8%) compared with smooth magnetic particles (SMPs, 35.7% ± 5.7%). Under the assistance of machine learning by combining with prostate-specific antigen (PSA) and free to total PSA (F/T-PSA), the NFMPs strategy demonstrates high sensitivity (100%), high specificity (93.3%), and a high area under the curve (AUC) value (98.1%) for clinical diagnosis of prostate cancer in the PSA gray zone. The NFMPs are anticipated as an efficient platform for CTCs-based liquid biopsy toward early cancer diagnosis and prognosis evaluation
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|a Journal Article
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|a circulating tumor cells
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|a immune cells
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|a magnetic particles
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|a prostate cancer
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|a prostate-specific antigen (PSA) gray zone
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|a Prostate-Specific Antigen
|2 NLM
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| 650 |
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|a EC 3.4.21.77
|2 NLM
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| 700 |
1 |
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|a Zhang, Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Yongyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Xinyi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bu, Fanqin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Dandan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Chen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ge, Liyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Shaohui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Zonglong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhanyi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Duan, Peichen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Min, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shudong
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Shutao
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 48 vom: 29. Nov., Seite e2303821
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:48
|g day:29
|g month:11
|g pages:e2303821
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202303821
|3 Volltext
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