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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109746
|2 doi
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|a pubmed24n1204.xml
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|a (DE-627)NLM361238703
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|a (NLM)37625669
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|a (PII)S1521-6616(23)00509-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Michailidou, Despina
|e verfasserin
|4 aut
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| 245 |
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|a Mitochondrial-mediated inflammation and platelet activation in giant cell arteritis
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.10.2023
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|a Date Revised 04.10.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Markers of extracellular mitochondria are present in giant cell arteritis (GCA) patients. However, their role in promoting inflammation and platelet activation is no known. To investigate this, isolated mitochondria were opsonized with plasma from GCA patients or healthy individuals and incubated with peripheral blood mononuclear cells (PBMCs) or platelets and assessed for inflammatory cytokine production and platelet activation. Plasma from GCA patients promoted increased mitochondrial-mediated cytokine production by PBMCs as compared to healthy controls (p < 0.05). Mitochondria opsonized with plasma factors from patients with GCA induced higher platelet activation as compared to mitochondria opsonized with plasma factors from healthy individuals (p = 0.0015). Platelet levels of P-selectin were associated with disease activity in GCA (r = 0.34, p = 0.01). GCA patients have impaired ability to regulate the clearance of extracellular mitochondria, possibly contributing to excessive inflammation and platelet activation. Targeting key drivers of mitochondrial extrusion and/or their clearance could lead to new therapeutic interventions in GCA
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Cytokines
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|a Giant cell arteritis
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|a Mitochondria
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|a P-selectin
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|a PBMC
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|a Platelets
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|a Cytokines
|2 NLM
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|a Grayson, Peter C
|e verfasserin
|4 aut
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|a Hermanson, Payton
|e verfasserin
|4 aut
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|a Chapa, Jorge Armando Gonzalez
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|4 aut
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|a Cuthbertson, David
|e verfasserin
|4 aut
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|a Khalidi, Nader A
|e verfasserin
|4 aut
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|a Koening, Curry L
|e verfasserin
|4 aut
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|a Langford, Carol A
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|4 aut
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|a McAlear, Carol A
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|4 aut
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|a Moreland, Larry W
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|4 aut
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|a Pagnoux, Christian
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|4 aut
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|a Seo, Philip
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|4 aut
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|a Sreih, Antoine G
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|4 aut
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|a Warrington, Kenneth J
|e verfasserin
|4 aut
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|a Monach, Paul A
|e verfasserin
|4 aut
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|a Merkel, Peter A
|e verfasserin
|4 aut
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|a Lood, Christian
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 255(2023) vom: 23. Okt., Seite 109746
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:255
|g year:2023
|g day:23
|g month:10
|g pages:109746
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|u http://dx.doi.org/10.1016/j.clim.2023.109746
|3 Volltext
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