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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c01270
|2 doi
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|a pubmed24n1509.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Lehman, Sean E
|e verfasserin
|4 aut
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| 245 |
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|a Particle Metrology Approach to Understanding How Storage Conditions Affect Long-Term Liposome Stability
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 06.09.2023
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|a Date Revised 22.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Lipid nanoparticles are a generic type of nanomaterial with broad applicability in medicine as drug delivery vehicles. Liposomes are a subtype of lipid nanoparticles and, as a therapeutic platform, can be loaded with a genetic material or pharmaceutical agents for use as drug treatments. An open question for these types of lipid nanoparticles is what factor(s) affect the long-term stability of the particles. The stability of the particle is of great interest to understand and predict the effective shelf-life and storage requirements. In this report, we detail a one-year study of liposome stability as a function of lipid composition, buffer composition/pH, and storage temperature. This was done in aqueous solution without freezing. The effect of lipid composition is shown to be a critical factor when evaluating stability of the measured particle size and number concentration. Other factors (i.e., storage temperature and buffer pH/composition) were shown to be less critical but still have some effect. The stability of these particles informs formulation and optimal storage requirements and assists with future developmental planning of a NIST liposome-based reference material. This work also highlights the complex nature of long-term soft particle storage in biopharmaceutical applications
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|a Journal Article
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|a Liposomes
|2 NLM
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| 650 |
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|a Biological Products
|2 NLM
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| 650 |
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|a Biotin
|2 NLM
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|a 6SO6U10H04
|2 NLM
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| 650 |
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|a Lipids
|2 NLM
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| 700 |
1 |
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|a Benkstein, Kurt D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cleveland, Thomas E
|c 4th
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Anderson, Kyle W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Carrier, Michael J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vreeland, Wyatt N
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 39(2023), 35 vom: 05. Sept., Seite 12313-12323
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:39
|g year:2023
|g number:35
|g day:05
|g month:09
|g pages:12313-12323
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|u http://dx.doi.org/10.1021/acs.langmuir.3c01270
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