Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations

Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 255(2023) vom: 01. Okt., Seite 109737
1. Verfasser: Wang, Chuang-Wei (VerfasserIn)
Weitere Verfasser: Wu, Ming-Ying, Chen, Chun-Bing, Lin, Wei-Chen, Wu, Jennifer, Lu, Chun-Wei, Chen, Wei-Ti, Wang, Fang-Ying, Hui, Rosaline Chung-Yee, Chi, Min-Hui, Chiu, Tsu-Man, Chang, Ya-Ching, Lin, Jing Yi, Lin, Yang Yu-Wei, Tsai, Wan-Ting, Hung, Shuen-Iu, Chung, Wen-Hung
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Alopecia areata Autoimmune disease COVID-19 vaccine Granulysin Lymphocyte activation test Polyethylene glycol Spike protein COVID-19 Vaccines mehr... Spike Glycoprotein, Coronavirus spike protein, SARS-CoV-2
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
BACKGROUND: The clinical characteristics and pathomechanism for immune-mediated alopecia following COVID-19 vaccinations are not clearly characterized
OBJECTIVE: We investigated the causality and immune mechanism of COVID-19 vaccines-related alopecia areata (AA)
STUDY DESIGN: 27 new-onset of AA patients after COVID-19 vaccinations and 106 vaccines-tolerant individuals were enrolled from multiple medical centers for analysis
RESULTS: The antinuclear antibody, total IgE, granulysin, and PARC/CCL18 as well as peripheral eosinophil count were significantly elevated in the patients with COVID-19 vaccines-related AA compared with those in the tolerant individuals (P = 2.03 × 10-5-0.039). In vitro lymphocyte activation test revealed that granulysin, granzyme B, and IFN-γ released from the T cells of COVID-19 vaccines-related AA patients could be significantly increased by COVID-19 vaccine excipients (polyethylene glycol 2000 and polysorbate 80) or spike protein (P = 0.002-0.04)
CONCLUSIONS: Spike protein and excipients of COVID-19 vaccines could trigger T cell-mediated cytotoxicity, which contributes to the pathogenesis of immune-mediated alopecia associated with COVID-19 vaccines
Beschreibung:Date Completed 02.10.2023
Date Revised 02.10.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109737