Pathogenicity characterization of nocardiosis in orange-spotted grouper (Epinephelus coioides) via exposure to nine distinct isolates of Nocardia seriolae and four administrative routes

© 2023 John Wiley & Sons Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Journal of fish diseases. - 1998. - 46(2023), 11 vom: 12. Nov., Seite 1257-1268
1. Verfasser: Nguyen, Phuong (VerfasserIn)
Weitere Verfasser: Giovanni, Andre, Cheng, Li-Wu, Wang, Pei-Chi, Chen, Shih-Chu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Journal of fish diseases
Schlagworte:Journal Article administrative routes chronic disease granulomatous nocardiosis orange-spotted grouper pathogenicity
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520 |a Nocardia seriolae causes chronic nocardiosis in various marine and freshwater aquatic animals; however, grouper species have rarely been investigated. This study evaluated the pathogenicity of nocardiosis following N. seriolae infection in the orange-spotted grouper Epinephelus coioides. Nine identified genetic isolates of N. seriolae were tested in vivo using the intraperitoneal method and observed daily for 35 days. The most virulent isolate was then used to evaluate transmission through different routes (intraperitoneal IP, intramuscular IM, oral OR, and immersion IS) in the same fish model and was observed daily for 42 days. The results showed mild variation in virulence among N. seriolae isolates. AOD107132-2 K and OT103003-N11 strains displayed the highest and lowest risk virulence, respectively, based on the accumulation and kinetics of mortality. IM and IP administrations showed an early phase response with early mortality by 5 dpc (30%-100%), while slower kinetics of nocardiosis occurred in the OR and IS routes with slow mortality at 35 dpc (4%-8%). Histopathology revealed typical granulomas, confirming the progression of nocardiosis in the diseased fish. These results provide the basis for further studies on the virulence profile of N. seriolae in Taiwan and a well-suited route of administration in orange-spotted groupers for further prevention development 
650 4 |a Journal Article 
650 4 |a administrative routes 
650 4 |a chronic disease 
650 4 |a granulomatous 
650 4 |a nocardiosis 
650 4 |a orange-spotted grouper 
650 4 |a pathogenicity 
700 1 |a Giovanni, Andre  |e verfasserin  |4 aut 
700 1 |a Cheng, Li-Wu  |e verfasserin  |4 aut 
700 1 |a Wang, Pei-Chi  |e verfasserin  |4 aut 
700 1 |a Chen, Shih-Chu  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Journal of fish diseases  |d 1998  |g 46(2023), 11 vom: 12. Nov., Seite 1257-1268  |w (DE-627)NLM098166034  |x 1365-2761  |7 nnns 
773 1 8 |g volume:46  |g year:2023  |g number:11  |g day:12  |g month:11  |g pages:1257-1268 
856 4 0 |u http://dx.doi.org/10.1111/jfd.13845  |3 Volltext 
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