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|a 10.1002/adma.202305287
|2 doi
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|a eng
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| 100 |
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|a Xu, Meng
|e verfasserin
|4 aut
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| 245 |
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|a "Ice and Fire" Supramolecular Cell-Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Antitumor Immunity
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|c 2023
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 17.02.2024
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|a Date Revised 17.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Cancer recurrence and metastasis are two major challenges in the current clinical therapy. In this work, a novel diketopyrrolopyrrole-based photothermal reagent (DCN) with unique J-aggregation-induced redshift is synthesized to achieve efficient tumor thermal ablation under safe power (0.33 W cm-2 ). Meanwhile, S-nitroso-N-acetylpenicillamine (SNAP) is co-loaded with near-infrared-absorbing DCN in amphiphilic polymers to realize heat-induced massive release of nitric oxide (NO), which can form oxidant peroxynitrite (ONOO- ) to active matrix metalloproteinases (MMPs), thereby degrading the compact tumor extracellular matrix to improve the ablation depth and infiltration of immune cells. Through a facile supramolecular assembly method, the DCN/SNAP nanoparticles are anchored to liquid-nitrogen-frozen cancer cells, achieving enhanced antitumor immune responses and effective inhibition of distant tumors and pulmonary metastases after only one treatment. The safety and effectiveness of this supramolecular cell-conjugation platform are verified by 2D/3D cellular experiments and bilateral tumor model, confirming the thermal-ablation-gas-permeation-antigen-presentation therapeutic mode has promising anticancer prospects
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|a Journal Article
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|a cancer immunotherapy
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|a cancer recurrence
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|a supramolecular systems
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| 650 |
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|a therapeutic tumor cells
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| 650 |
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4 |
|a tumor metastasis
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| 700 |
1 |
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|a Zha, Haidong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Jiamao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Simon Ming-Yuen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Ruibing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Ying
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 51 vom: 25. Dez., Seite e2305287
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|g volume:35
|g year:2023
|g number:51
|g day:25
|g month:12
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|u http://dx.doi.org/10.1002/adma.202305287
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