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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202305163
|2 doi
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|a pubmed24n1201.xml
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|a (DE-627)NLM360447155
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|a (NLM)37545041
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Zhao, Xueze
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Near-Infrared Self-Assembled Hydroxyl Radical Generator Based on Photoinduced Cascade Electron Transfer for Hypoxic Tumor Phototherapy
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 03.11.2023
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|a Date Revised 03.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a The hydroxyl radical (•OH) is an extremely potent reactive oxygen species that plays a crucial role in photooxidations within the realm of hypoxic tumor therapy. However, the current methods for •OH photogeneration typically rely on inorganic materials that require UV/vis light excitation. Consequently, photogenerators based on organic molecules, especially those utilizing near-infrared (NIR) light excitation, are rare. In this study, the concept of photoinduced cascade charge transfer (PICET), which utilizes NIR heavy-atom-free photosensitizers (ANOR-Cy5) to generate •OH is introduced. The ANOR-Cy5 photosensitizer, with its flexible hydrophobic structure, enables the formation of nanoparticles in aqueous solutions through molecular assembly. PICET involves a symmetry-breaking charge separation-induced localized charge-separated state, transitioning to a delocalized charge-separated state, which governs the efficiency of •OH generation. Thanks to the oxygen-independent nature of •OH generation and its robust oxidative properties, the ANOR-Cy5-based photosensitizer demonstrates highly effective photoinduced anti-cancer effects, even under severely hypoxic conditions. This discovery emphasizes the potential for achieving •OH photogeneration using a single organic molecule through the engineering of molecular self-assembly, thereby opening up new possibilities for phototherapy and beyond
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|a Journal Article
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|a hydroxyl radical
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|a hypoxic tumor therapy
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|a molecular self-assembly
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4 |
|a near-infrared light
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| 650 |
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|a photoinduced cascade electron transfer
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|a cyanine dye 5
|2 NLM
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a Hydroxyl Radical
|2 NLM
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| 650 |
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|a 3352-57-6
|2 NLM
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| 700 |
1 |
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|a He, Shan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Junfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Junying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zong, Shenglin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Guohui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Du, Jianjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fan, Jiangli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Peng, Xiaojun
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 44 vom: 06. Nov., Seite e2305163
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:44
|g day:06
|g month:11
|g pages:e2305163
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202305163
|3 Volltext
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