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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109712
|2 doi
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|a pubmed25n1199.xml
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|a (DE-627)NLM360066313
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|a (NLM)37506745
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|a (PII)S1521-6616(23)00475-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Allers, Kristina
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Cytolytic CD8+ T cell response to SARS-CoV-2 and non-SARS-CoV-2-related viruses is associated with severe manifestation of COVID-19
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.08.2023
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|a Date Revised 22.08.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a Little is known about the CD8+ T cell functionality in the coronavirus disease 2019 (COVID-19). Therefore, we examined twenty-five hospitalized COVID-19 patients with moderate (MD) or severe disease (SD) as well as seventeen SARS-CoV-2-unexposed persons regarding the cytolytic and cytokine-producing reactivity of their CD8+ T cells. Reactive CD8+ T cells were detectable in 90% of the unexposed persons, confirming high cross-reactive immune memory in the general population. Compared to unexposed persons and MD patients, SD patients had higher numbers of SARS-CoV-2 reactive CD8+ T cells with cytolytic function that can simultaneously produce inflammatory cytokines. In addition, SD patients showed higher CD8+ T cell reactivity against non-SARS-CoV-2-related viruses, which was mainly mediated by cytolytic response. Sequence alignments showed that cross-reactivities with the Spike protein could contribute to the expansion of such cells. Since insufficiently regulated cytolytic CD8+ T cells can damage peripheral and vascular tissue structures, high levels of both SARS-CoV-2-reactive and heterologously activated cytolytic CD8+ T cells could favor severe disease progression
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Bystander activation
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| 650 |
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4 |
|a CD8(+) T cell response
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| 650 |
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4 |
|a COVID-19
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| 650 |
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4 |
|a Cytolytic CD8(+) T cells
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| 650 |
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4 |
|a Heterologous T cell activation
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| 650 |
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4 |
|a SARS-CoV-2
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| 700 |
1 |
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|a Moos, Verena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hofmann, Jörg
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Witkowski, Mario
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Haibel, Hildrun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Angermair, Stefan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schneider, Thomas
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 254(2023) vom: 14. Sept., Seite 109712
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:254
|g year:2023
|g day:14
|g month:09
|g pages:109712
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2023.109712
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 254
|j 2023
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|h 109712
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