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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202306616
|2 doi
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|a pubmed24n1415.xml
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|a (DE-627)NLM359895875
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|a (NLM)37489377
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhang, Jing
|e verfasserin
|4 aut
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|a A New Strategy to Elevate Absorptivity of AIEgens for Intensified NIR-II Emission and Synergized Multimodality Therapy
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.11.2023
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|a Date Revised 21.05.2024
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|a published: Print-Electronic
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|a ErratumIn: Adv Mater. 2024 May 21;:e2402186. - PMID 38772006
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a High-efficiency absorptivity is crucial for the construction of high-performance luminescent materials, especially the long-wavelength near-infrared II (NIR-II) materials; thus seeking an efficient and universal strategy to elevate the absorptivity is extremely important but is still an intractable challenge. In this work, a simple but efficient design strategy is discovered, involving the introduction of gold(I) unit that could effectively elevate the absorptivity of aggregation-induced-emission luminogens (AIEgens). As a result of the efficient elevation of absorptivity, the representative AIE-active TBTP-Au shows more superior NIR-II (1220 nm) luminescence, much higher photothermal conversion efficiency, and unique intracellular reactive oxygen species (ROS) generating ability compared with that of the TBTP ligand. Taking advantage of these improvements, the fabricated tumor-targeting TBTP-Au-cRGD nanoparticles achieve specific NIR-II tumorous imaging in vivo and exert high-efficiency cancer therapy via the synergistic chemotherapy and photothermal therapy. Thus, this work provides a new and efficient strategy to construct high-absorption luminescent materials and demonstrates the great potential of gold(I)-based AIEgens as multifunctional theranostic agents
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|a Journal Article
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|a NIR-II imaging
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|a aggregation-induced emission
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|a gold(I) complexes
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|a multimodality therapy
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Liu, Wenjing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yangjing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jianyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Pengfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, Guorui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Ben Zhong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 47 vom: 02. Nov., Seite e2306616
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:35
|g year:2023
|g number:47
|g day:02
|g month:11
|g pages:e2306616
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|u http://dx.doi.org/10.1002/adma.202306616
|3 Volltext
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