Synchronous Diagnosis of Respiratory Viruses Variants via Receptonics Based on Modeling Receptor-Ligand Dynamics

Synchronous Diagnosis of Respiratory Viruses Variants via Receptonics Based on Modeling Receptor-Ligand Dynamics

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 9 vom: 08. März, Seite e2303079
1. Verfasser: Seo, Sung Eun (VerfasserIn)
Weitere Verfasser: Kim, Kyung Ho, Ha, Siyoung, Oh, Hanseul, Kim, Jinyeong, Kim, Soomin, Kim, Lina, Seo, Minah, An, Jai Eun, Park, Yoo Min, Lee, Kyoung G, Kim, Yu Kyung, Kim, Woo-Keun, Hong, Jung Joo, Song, Hyun Seok, Kwon, Oh Seok
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article field-effect transistors interfacing chemistry portable devices receptonics respiratory viruses Ligands Graphite 7782-42-5
Beschreibung
Zusammenfassung:© 2023 Wiley-VCH GmbH.
The transmission and pathogenesis of highly contagious fatal respiratory viruses are increasing, and the need for an on-site diagnostic platform has arisen as an issue worldwide. Furthermore, as the spread of respiratory viruses continues, different variants have become the dominant circulating strains. To prevent virus transmission, the development of highly sensitive and accurate on-site diagnostic assays is urgently needed. Herein, a facile diagnostic device is presented for multi-detection based on the results of detailed receptor-ligand dynamics simulations for the screening of various viral strains. The novel bioreceptor-treated electronics (receptonics) device consists of a multichannel graphene transistor and cell-entry receptors conjugated to N-heterocyclic carbene (NHC). An ultrasensitive multi-detection performance is achieved without the need for sample pretreatment, which will enable rapid diagnosis and prevent the spread of pathogens. This platform can be applied for the diagnosis of variants of concern in clinical respiratory virus samples and primate models. This multi-screening platform can be used to enhance surveillance and discriminate emerging virus variants before they become a severe threat to public health
Beschreibung:Date Completed 04.03.2024
Date Revised 04.03.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202303079