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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202303567
|2 doi
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|a pubmed24n1198.xml
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|a (NLM)37466394
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|a eng
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|a Yin, Na
|e verfasserin
|4 aut
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|a A Cholesterol Metabolic Regulated Hydrogen-Bonded Organic Framework (HOF)-Based Biotuner for Antibody Non-Dependent Immunotherapy Tailored for Glioblastoma
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 03.11.2023
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|a Date Revised 03.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a The metabolic reprogramming of glioblastoma (GBM) poses a tremendous obstacle to effective immunotherapy due to its impact on the immunosuppressive microenvironment. In this work, a hydrogen-bonded organic framework (HOF) specifically designed for GBM immunotherapy is developed, taking advantage of the relatively isolated cholesterol metabolism microenvironment in the central nervous system (CNS). The HOF-based biotuner regulates extra/intracellular cholesterol metabolism, effectively blocking the programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) pathway and reducing 2B4 expression. This metabolically disrupts the immunosuppressive microenvironment of GBM and rejuvenates CD8+ T cells. Moreover, cholesterol metabolism regulation offers additional benefits in treating GBM invasion. Furthermore, tumor microenvironment (TME)-initiated chemiexcited photodynamic therapy (PDT) is enhanced during the regulation of cholesterol metabolism, and the biotuner can effectively trigger immunogenic cell death (ICD) and increase the infiltration of cytotoxic T lymphocytes (CTLs) in GBM. By reversing the immunosuppressive microenvironment and bolstering chemiexcited-PDT, this approach invigorates efficient antibody non-dependent immunotherapy for GBM. This study provides a model for enhancing immunotherapy through cholesterol metabolism regulation and explores the feasibility of a "metabolic checkpoint" strategy in GBM treatment
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4 |
|a Journal Article
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| 650 |
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4 |
|a checkpoint blockade
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| 650 |
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4 |
|a cholesterol metabolism
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| 650 |
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4 |
|a hydrogen-bonded organic frameworks
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| 650 |
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4 |
|a immunotherapy
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| 650 |
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4 |
|a orthotopic glioblastoma
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| 650 |
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4 |
|a photodynamic therapy
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| 650 |
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|a Antibodies
|2 NLM
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| 700 |
1 |
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|a Wang, Yinghui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Niu, Rui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shuai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lv, Zhijia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Shuyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Xiaogang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hongjie
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 44 vom: 01. Nov., Seite e2303567
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2023
|g number:44
|g day:01
|g month:11
|g pages:e2303567
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202303567
|3 Volltext
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