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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1155/2023/6762225
|2 doi
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|a pubmed25n1198.xml
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wu, Bingyuan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a White Matter Microstructural Alterations over the Year after Acute Ischemic Stroke in Patients with Baseline Impaired Cognitive Functions
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 18.07.2023
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|a Date Revised 19.07.2023
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|a published: Electronic-eCollection
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|a Citation Status MEDLINE
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|a Copyright © 2023 Bingyuan Wu et al.
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|a Background: The disruption of white matter (WM) integrity is related to poststroke cognitive impairment (PSCI). The exploration of WM integrity alterations in the chronic stage of acute ischemic stroke (AIS) may help to improve the long-term outcomes of PSCI
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|a Methods: Sixty patients showing impaired cognitive functions within 3 days after AIS (baseline) and 25 healthy controls underwent diffusion kurtosis imaging scan and cognitive assessment at baseline and 1 year. Based on the tract-based spatial statistics (TBSS), kurtosis fractional anisotropy (KFA) and mean kurtosis (MK) were compared in WM tracts between the groups
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|a Results: One year after AIS, 25 patients were diagnosed with PSCI and 35 patients with non-cognitive impairment (NCI). Compared with baseline, cognitive performance improved in 54 patients and remained unchanged in 6 patients at 1 year. TBSS analysis showed that there were no significant differences in WM tract integrity between the AIS and control groups at baseline (P > 0.05). Compared with the control group, the KFA and MK in multiple WM tracts in the AIS group decreased significantly at 1 year (P < 0.05). Longitudinal analysis showed that the KFA and MK of multiple WM tracts recorded at 1 year were significantly lower than those recorded at baseline in the AIS, PSCI, and NCI groups (P < 0.05), and PSCI group had a faster degeneration than NCI group (P < 0.05)
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|a Conclusion: The finding suggests that the patients with baseline impaired cognitive functions still have WM microstructural damages at 1 year poststroke, even if their cognitive function has improved or returned to normal. Cautions should be taken against the possible negative impact of these changes on long-term cognition
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|a Journal Article
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| 700 |
1 |
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|a Guo, Shida
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Xiuqin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Geng, Zuojun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Qi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Neural plasticity
|d 1998
|g 2023(2023) vom: 05., Seite 6762225
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnas
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| 773 |
1 |
8 |
|g volume:2023
|g year:2023
|g day:05
|g pages:6762225
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| 856 |
4 |
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|u http://dx.doi.org/10.1155/2023/6762225
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