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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.jplph.2023.154049
|2 doi
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|a pubmed24n1197.xml
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|a (DE-627)NLM359240933
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|a (NLM)37423042
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|a (PII)S0176-1617(23)00143-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Xiao, Zejun
|e verfasserin
|4 aut
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|a A MAPK signaling cascade regulates the fusaric acid-induced cell death in Arabidopsis
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.08.2023
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|a Date Revised 14.08.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier GmbH. All rights reserved.
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|a Mycotoxin contamination of foods and feeds is a global problem. Fusaric acid (FA) is a mycotoxin produced by Fusarium species that are phytopathogens of many economically important plant species. FA can cause programmed cell death (PCD) in several plant species. However, the signaling mechanisms of FA-induced cell death in plants are largely unknown. Here we showed that FA induced cell death in the model plant Arabidopsis thaliana, and MPK3/6 phosphorylation was triggered by FA in Arabidopsis. Both the acid nature and the radical of FA are required for its activity in inducing MPK3/6 activation and cell death. Expression of the constitutively active MKK5DD resulted in the activation of MPK3/6 and promoted the FA-induced cell death. Our work demonstrates that the MKK5-MPK3/6 cascade positively regulates FA-induced cell death in Arabidopsis and also provides insight into the mechanisms of how cell death is induced by FA in plants
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|a Journal Article
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|a Arabidopsis thaliana
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|a Cell death
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|a Fusaric acid
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|a MAPK cascade
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|a MKK5
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|a MPK3/6 activation
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|a Fusaric Acid
|2 NLM
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|a JWJ963070N
|2 NLM
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| 650 |
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|a Mitogen-Activated Protein Kinases
|2 NLM
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|a EC 2.7.11.24
|2 NLM
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|a Mitogen-Activated Protein Kinase Kinases
|2 NLM
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|a EC 2.7.12.2
|2 NLM
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a Mycotoxins
|2 NLM
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| 700 |
1 |
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|a Huang, Guozhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Dongping
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of plant physiology
|d 1979
|g 287(2023) vom: 24. Aug., Seite 154049
|w (DE-627)NLM098174622
|x 1618-1328
|7 nnns
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| 773 |
1 |
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|g volume:287
|g year:2023
|g day:24
|g month:08
|g pages:154049
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|u http://dx.doi.org/10.1016/j.jplph.2023.154049
|3 Volltext
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|d 287
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