Langmuir-Blodgett-Mediated Formation of Antibacterial Microneedles for Long-Term Transdermal Drug Delivery

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 38 vom: 12. Sept., Seite e2303388
1. Verfasser:	Lu, Ziyi (VerfasserIn)
Weitere Verfasser:	Du, Shan, Li, Jiaxun, Zhang, Min, Nie, Huali, Zhou, Xiaojun, Li, Fulun, Wei, Xinwei, Wang, Jinqiang, Liu, Fuyao, He, Chuanglong, Yang, Guang, Gu, Zhen
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article antibacterial nanoparticles langmuir-Blodgett coating technique microneedles nanomedicine skin infection transdermal drug delivery Anti-Bacterial Agents

Beschreibung
Zusammenfassung:	© 2023 Wiley-VCH GmbH. Microneedles (MNs) have become versatile platforms for minimally invasive transdermal drug delivery devices. However, there are concerns about MN-induced skin infections with long-term transdermal administration. Using the Langmuir-Blodgett (LB) technique, a simple method for depositing antibacterial nanoparticles of various shapes, sizes, and compositions onto MNs is developed. This strategy has merits over conventional dip coating techniques, including controlled coating layers, uniform and high coverage, and a straightforward fabrication process. This provides MNs with a fast-acting and long-lasting antibacterial effect. This study demonstrates that antibacterial MNs achieve superior bacterial elimination in vitro and in vivo without sacrificing payload capacity, drug release, or mechanical strength. It is believed that such a functional nanoparticle coating technique offers a platform for the expansion of MNs function, especially in long-term transdermal drug delivery fields
Beschreibung:	Date Completed 22.09.2023 Date Revised 22.09.2023 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202303388