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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c00389
|2 doi
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|a pubmed24n1195.xml
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|a (DE-627)NLM35867669X
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|a (NLM)37366321
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zheng, Chuanbao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Modular Design for Proteins Assembling into Antifouling Coatings
|b Case of Gold Surfaces
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.07.2023
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|a Date Revised 18.07.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We analyze modularity for a B-M-E triblock protein designed to self-assemble into antifouling coatings. Previously, we have shown that the design performs well on silica surfaces when B is taken to be a silica-binding peptide, M is a thermostable trimer domain, and E is the uncharged elastin-like polypeptide (ELP), E = (GSGVP)40. Here, we demonstrate that we can modulate the nature of the substrate on which the coatings form by choosing different solid-binding peptides as binding domain B and that we can modulate antifouling properties by choosing a different hydrophilic block E. Specifically, to arrive at antifouling coatings for gold surfaces, as binding block B we use the gold-binding peptide GBP1 (with the sequence MHGKTQATSGTIQS), while we replace the antifouling blocks E by zwitterionic ELPs of different lengths, EZn = (GDGVP-GKGVP)n/2, with n = 20, 40, or 80. We find that even the B-M-E proteins with the shortest E blocks make coatings on gold surfaces with excellent antifouling against 1% human serum (HS) and reasonable antifouling against 10% HS. This suggests that the B-M-E triblock protein can be easily adapted to form antifouling coatings on any substrate for which solid-binding peptide sequences are available
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Peptides
|2 NLM
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|a Silicon Dioxide
|2 NLM
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|a 7631-86-9
|2 NLM
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| 700 |
1 |
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|a Alvisi, Nicolò
|e verfasserin
|4 aut
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| 700 |
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|a de Haas, Robbert Jan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhisen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zuilhof, Han
|e verfasserin
|4 aut
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| 700 |
1 |
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|a de Vries, Renko
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 39(2023), 27 vom: 11. Juli, Seite 9290-9299
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:39
|g year:2023
|g number:27
|g day:11
|g month:07
|g pages:9290-9299
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|u http://dx.doi.org/10.1021/acs.langmuir.3c00389
|3 Volltext
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