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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109679
|2 doi
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|a pubmed24n1194.xml
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|a (NLM)37336253
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Fragoulis, George E
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Distinct innate and adaptive immunity phenotypic profile at the circulating single-cell level in Psoriatic Arthritis
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| 264 |
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 26.07.2023
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|a Date Revised 26.07.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2023 Elsevier Inc. All rights reserved.
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|a Mass cytometry was employed to investigate 47 circulating leukocyte subsets in patients with active psoriatic arthritis (PsA, n = 16) compared to healthy controls (n = 13), seropositive (RF and/or anti-CCP, n = 12) and seronegative (n = 9) RA patients. Comparing PsA to controls, different cell frequencies were found in both innate and adaptive immunity cell subsets, as well as in cells bridging innate and adaptive immunity. In some T cell subsets increased costimulatory molecules' expression in PsA, was also noted.No changes were observed in patients who remained disease-active after 3 months of treatment, in contrast to those who achieved remission/low-disease activity. Comparing PsA to seropositive RA, elevated frequencies of naïve and activated CD8+ T cells, B cells, MAIT/iNKT and ILCs were found, while the opposite was the case for terminal effector, senescent, and Th2-like cells. Strikingly, the composition of the leukocyte pool in PsA was comparable to seronegative RA, providing evidence for the pathogenetic similarities between these two entities
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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4 |
|a CyTOF
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| 650 |
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4 |
|a Immunophenotyping
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| 650 |
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4 |
|a Mass cytometry
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| 650 |
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4 |
|a Peripheral blood
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| 650 |
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4 |
|a Psoriatic arthritis
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| 700 |
1 |
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|a Vetsika, Eleni-Kyriaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kyriakidi, Maria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Verrou, Kleio-Maria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kollias, George
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tektonidou, Maria G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a McInnes, Iain B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sfikakis, Petros P
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 253(2023) vom: 01. Aug., Seite 109679
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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|g volume:253
|g year:2023
|g day:01
|g month:08
|g pages:109679
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|u http://dx.doi.org/10.1016/j.clim.2023.109679
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