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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202301765
|2 doi
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|a pubmed24n1193.xml
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|a (DE-627)NLM358198488
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|a (NLM)37318249
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Lan, Jinze
|e verfasserin
|4 aut
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|a A Rapid Self-Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 22.09.2023
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|a Date Revised 22.09.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self-pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive exudates with ≈30 times enhancement in efficiency compared with the pure hydrogel, and effectively promote burn wound healing. A creaming-assistant emulsion interfacial polymerization approach is proposed to create the hydrophilic fractal hydrogel microchannels in the self-pumping organohydrogel through a dynamic floating-colliding-coalescing process of organogel precursor droplets. In a murine burn wound model, the rapid self-pumping organohydrogel dressings can markedly reduce dermal cavity by ≈42.5%, accelerate blood vessel regeneration by ≈6.6 times, and hair follicle regeneration by ≈13.5 times, compared with the commercial dressing (Tegaderm). This study paves an avenue for designing high-performance functional burn wound dressings
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|a Journal Article
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|a burn wound healing
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|a fractal microchannels
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|a organohydrogels
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|a rapid absorption
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|a self-pumping
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|a Hydrogels
|2 NLM
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1 |
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|a Shi, Lianxin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiao, Wuyi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xiaobin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Shutao
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 38 vom: 19. Sept., Seite e2301765
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:35
|g year:2023
|g number:38
|g day:19
|g month:09
|g pages:e2301765
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|u http://dx.doi.org/10.1002/adma.202301765
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