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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-023-02675-2
|2 doi
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|a pubmed24n1193.xml
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|a (DE-627)NLM358023807
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|a (NLM)37300635
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Korkmaz, Nuh
|e verfasserin
|4 aut
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|a Toxic effects of the synthetic pyrethroid permethrin on the hematological parameters and antioxidant enzyme systems of the freshwater fish Cyprinus carpio L
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.06.2023
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|a Date Revised 30.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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|a This study investigated changes in hematological and antioxidant parameters of carp exposed to two different doses of synthetic pyrethroid permethrin (control, vehicle, 10 ppm, and 20 ppm) for two different periods (4 days and 21 days). Hematological analyses were then performed on a veterinary Ms4 (Melet Schloesing, France) blood counter using commercially available kits (Cat. No. WD1153). Buege and Aust for MDA, Luck for CAT, McCord and Frivovich for SOD, Lawrence and Burk methods for GSH-Px were used to determine antioxidant parameters. Decreases in RBC count, Hb amount, Hct value, granulocyte ratios, and increases in total WBC and lymphocyte ratios were statistically significant in both dose groups treated with permethrin compared to the control group (p < 0.05). However, there was no statistically significant difference in monocyte ratios (p > 0.05). Overall, permethrin exposure caused an increase in MDA levels in the liver and gill tissues of carp in both dose and duration groups compared to the control group. Also, no statistically significant difference between the two dose groups in the liver tissue was observed in terms of duration (p > 0.05). Nonetheless, the increase in MDA levels in PERM10 and PERM20 dose groups in the gill tissues over 21 days was statistically significant (p < 0.05). Furthermore, permethrin exposure increased CAT, SOD, and GSH-Px enzyme activities in the gill tissue, while impacting in the opposite direction the liver tissue. Finally, regarding MDA, CAT, SOD, and GSH-Px levels, the control, and control acetone dose groups of all experimental groups were observed to be similar (p > 0.05). As a result, permethrin produced a toxic effect on Cyprinus carpio, triggering changes in blood parameters and inducing the antioxidant enzyme system
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|a Journal Article
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|a Antioxidant enzymes
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|a Cyprinus carpio
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|a Hematological parameters
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|a Permethrin
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|a Antioxidants
|2 NLM
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| 650 |
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|a Pyrethrins
|2 NLM
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| 650 |
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|a Permethrin
|2 NLM
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| 650 |
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|a 509F88P9SZ
|2 NLM
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| 650 |
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|a Superoxide Dismutase
|2 NLM
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| 650 |
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|a EC 1.15.1.1
|2 NLM
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| 700 |
1 |
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|a Uğurer, Orhan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Örün, İbrahim
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 32(2023), 5 vom: 10. Juli, Seite 646-655
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:32
|g year:2023
|g number:5
|g day:10
|g month:07
|g pages:646-655
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|u http://dx.doi.org/10.1007/s10646-023-02675-2
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